| Literature DB >> 23266229 |
Evangelos P Daskalopoulos1, Kevin C M Hermans, Ben J A Janssen, W Matthijs Blankesteijn.
Abstract
Wnt/frizzled signaling in the adult heart is quiescent under normal conditions; however it is reactivated after myocardial infarction (MI). Any intervention at the various levels of this pathway can modulate its signaling. Several studies have targeted Wnt/frizzled signaling after MI with the majority of them indicating that the inhibition of the pathway is beneficial since it improves infarct healing and prevents heart failure. This suggests that blocking the Wnt/frizzled signaling pathway could be a potential novel therapeutic target to prevent the adverse cardiac remodeling after MI.Entities:
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Year: 2012 PMID： 23266229 DOI： 10.1016/j.tcm.2012.09.010
Source DB: PubMed Journal: Trends Cardiovasc Med ISSN： 1050-1738 Impact factor: 6.677