Synthesis of ¹³C-labeled and functionalized Hyaluronan derivatives for biophysical studies and surface modifications.

A convergent synthesis of a tetrasaccharide partial sequence of (13)C-labeled Hyaluronan is presented. This tetrasaccharide can be used for biophysical studies as well as for surface modifications. Furthermore, tetrasaccharide 7 can be employed for the synthesis of additionally labeled higher oligomers of Hyaluronan on the basis of the presented methodology.