Abdel Aziz Baiomy1, Mohamed A Nassan2, Elsaeed M Abdellatif3, Ashraf Abdel Fattah4, Ahmed A H El-Fekey5, Abdel Bassit M Abdel Aal6. 1. Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt. 2. Lecturer, Pathology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. Electronic address: Moh_nassan@yahoo.com. 3. Professor of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Cairo), Al-Azhar University, Egypt. 4. Professor and Head of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt. 5. Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Cairo), Al-Azhar University, Egypt. 6. Professor, Surgery Department, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Zagazig University, Egypt.
Abstract
OBJECTIVE: The objective of this study was the evaluation of effects of locally administered zoledronic acid and alendronate on rate of osteogenesis in distracted mandible of dogs. STUDY DESIGN: Following mandibular corticotomy, bone segments were maintained in a neutral position by distractor for 7 days then distraction was initiated at a rate of 0.5 mm twice a day for 10 days to achieve a total distraction of 10 mm, followed by a consolidation period. Animals were divided into 3 equal groups according to the injected drug (saline solution [control], zoledronic acid, alendronate). The dogs were killed 2, 6, and 10 weeks following distraction and samples were collected for radiographic examination, assessment of bone mineral density, and histopathological evaluation. RESULTS: Radiographs and histopathological results pointed out that bone formation and maturation of experimental groups were faster than those of the control group. CONCLUSIONS: Local administration of zoledronic acid and alendronate proved to be effective in shortening the consolidation period.
OBJECTIVE: The objective of this study was the evaluation of effects of locally administered zoledronic acid and alendronate on rate of osteogenesis in distracted mandible of dogs. STUDY DESIGN: Following mandibular corticotomy, bone segments were maintained in a neutral position by distractor for 7 days then distraction was initiated at a rate of 0.5 mm twice a day for 10 days to achieve a total distraction of 10 mm, followed by a consolidation period. Animals were divided into 3 equal groups according to the injected drug (saline solution [control], zoledronic acid, alendronate). The dogs were killed 2, 6, and 10 weeks following distraction and samples were collected for radiographic examination, assessment of bone mineral density, and histopathological evaluation. RESULTS: Radiographs and histopathological results pointed out that bone formation and maturation of experimental groups were faster than those of the control group. CONCLUSIONS: Local administration of zoledronic acid and alendronate proved to be effective in shortening the consolidation period.