| Literature DB >> 23265877 |
Rohan A Limaye1, Virendra B Kumbhar, Arun D Natu, Madhusudan V Paradkar, Varsha S Honmore, Rubia R Chauhan, Suwarna P Gample, Dhiman Sarkar.
Abstract
One pot synthesis of 3-Aracylphthalide was accomplished in good yield by reacting 2-carboxy benzaldehyde with various aromatic methyl ketones in presence of methane sulphonic acid. Various phthalides thus obtained were characterized with spectral techniques. These phthalides were subjected to in vitro antitubercular screening against Mycobacterium tuberculosis H37Ra (MTB) by using XRMA protocol. Among the phthalides screened, four exhibited half maximal inhibitory concentration (IC(50)) in the range of 0.81-1.24 μg/ml thereby providing potential lead compounds for future drug discovery studies.Entities:
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Year: 2012 PMID： 23265877 DOI： 10.1016/j.bmcl.2012.11.097
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823