| Literature DB >> 23265326 |
William P Unsworth1, Katherine A Gallagher, Mickaël Jean, Jan Peter Schmidt, Louis J Diorazio, Richard J K Taylor.
Abstract
The synthesis of the two proposed structures of macrocyclic marine natural product 'upenamide is reported. The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction.Entities:
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Year: 2012 PMID： 23265326 DOI： 10.1021/ol3030764
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005