Literature DB >> 23265244

Immune responses and protective efficacy of a recombinant swinepox virus co-expressing HA1 genes of H3N2 and H1N1 swine influenza virus in mice and pigs.

Jiarong Xu1, Dongyan Huang, Jiaping Xu, Shichao Liu, Huixing Lin, Haodan Zhu, Bao Liu, Wen Chen, Chengping Lu.   

Abstract

The recombinant swine poxvirus rSPV/H3-2A-H1 co-expressing HA1 genes of H3N2 and H1N1 subtype SIV has been constructed and identified. Inoculations of rSPV/H3-2A-H1 yielded ELISA and neutralization antibodies against SIV H1N1 and H3N2, and elicited potent H1N1 and H3N2 SIV-specific INF-γ response from T-lymphocytes in mice and pigs in this study. Complete protection against SIV H1N1 or H3N2 challenge in pigs was observed.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23265244     DOI： 10.1016/j.vetmic.2012.11.026

Source DB:  PubMed          Journal:  Vet Microbiol        ISSN： 0378-1135            Impact factor:   3.293


  3 in total

Review 1.  The evolution of poxvirus vaccines.

Authors:  Lucas Sánchez-Sampedro; Beatriz Perdiguero; Ernesto Mejías-Pérez; Juan García-Arriaza; Mauro Di Pilato; Mariano Esteban
Journal:  Viruses       Date:  2015-04-07       Impact factor: 5.048

2.  Clinical differences between H3N2 and H1N1 influenza 2012 and lower respiratory tract infection found using a statistical classification approach.

Authors:  Dimitris Petridis; Paul Zarogoulidis; Anastasios Kallianos; Ioannis Kioumis; Georgia Trakada; Dionysios Spyratos; Antonis Papaiwannou; Konstantinos Porpodis; Haidong Huang; Aggeliki Rapti; Wolfgang Hohenforst-Schmidt; Konstantinos Zarogoulidis
Journal:  Ther Clin Risk Manag       Date:  2014-02-07       Impact factor: 2.423

3.  Swinepox virus vector-based vaccines: attenuation and biosafety assessments following subcutaneous prick inoculation.

Authors:  Xiaomin Yuan; Huixing Lin; Bin Li; Kongwang He; Hongjie Fan
Journal:  Vet Res       Date:  2018-02-07       Impact factor: 3.683
  3 in total

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