Continual NMR cardiography without gating: M-mode MR imaging.

A magnetic resonance (MR) pulse sequence was designed and implemented to examine the heart continually without gating, at rates in excess of 256 images in 7 seconds. The results are analogous to those of M-mode ultrasound, allowing interactive exploration of cardiac dynamics and flow in real time with full three-dimensional freedom of view. The technique is based on designed two-dimensional excitation pulses in which the magnetic field gradient is not constant, as in section-selection pulses, but varies in time to define a trajectory that results in a specified (eg, cylindric) region of excitation. The technique was implemented on a 1.5-T clinical imager with no special hardware and was tested on phantoms and volunteers. In human subjects, details of valve motion, intracardiac flow, and wall motion could be observed from moment to moment along optimal lines of sight selected interactively, with or without flow compensation and without gating. The momentary physiologic changes in chamber volumes and blood pool replenishment that occur during rhythm disturbances, the Valsalva maneuver, and simple breathing and breath-holding were readily demonstrated.