Literature DB >> 23264158

Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis.

Stan Tay1, I-Lynn Lee.   

Abstract

Potassium levels are regularly used as a prognostic factor to cease resuscitation in significant hypothermia. In this case report, we highlight how survival is still possible with extreme hyperkalaemia in severe hypothermia. We present a case of a 65-year-old Caucasian man who presented with metformin associated lactic acidosis. On presentation he had potassium of 9.1 mmol/l and a temperature of 31.5 °C. Cardiopulmonary resuscitation was commenced when he went into asystolic arrest. This presentation would commonly make attempts at resuscitation futile with a 100% death rate. However, with appropriate management this patient's condition improved and survival was possible. We provide evidence that survival is possible in profound hyperkalaemia and hypothermia. Effective cardiopulmonary resuscitation with early haemofiltration can be successful.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 23264158      PMCID: PMC4545000          DOI: 10.1136/bcr-2012-007804

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  24 in total

Review 1.  Serum potassium in lactic acidosis and ketoacidosis.

Authors:  M Fulop
Journal:  N Engl J Med       Date:  1979-05-10       Impact factor: 91.245

2.  Life-threatening hyperkalemia in severe heart failure.

Authors:  S C Chakko; J Frutchey; M Gheorghiade
Journal:  Am Heart J       Date:  1989-05       Impact factor: 4.749

3.  Hyperkalemia. A prognostic factor during acute severe hypothermia.

Authors:  M D Schaller; A P Fischer; C H Perret
Journal:  JAMA       Date:  1990-10-10       Impact factor: 56.272

4.  Changes in plasma potassium concentration during acute acid-base disturbances.

Authors:  H J Adrogué; N E Madias
Journal:  Am J Med       Date:  1981-09       Impact factor: 4.965

5.  Hemodialysis in the treatment of lactic acidosis in diabetics treated by metformin: a study of metformin elimination.

Authors:  J D Lalau; M Andrejak; P Morinière; B Coevoet; X Debussche; P F Westeel; A Fournier; J Quichaud
Journal:  Int J Clin Pharmacol Ther Toxicol       Date:  1989-06

6.  Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study.

Authors:  D J Cooper; K R Walley; B R Wiggs; J A Russell
Journal:  Ann Intern Med       Date:  1990-04-01       Impact factor: 25.391

7.  Effects of acute hypothermia and beta-adrenergic receptor blockade on serum potassium concentration in rats.

Authors:  J Sprung; E Y Cheng; S Gamulin; J P Kampine; Z J Bosnjak
Journal:  Crit Care Med       Date:  1991-12       Impact factor: 7.598

8.  Perfusion without systemic heparinization for rewarming in accidental hypothermia.

Authors:  L K von Segesser; E Garcia; M Turina
Journal:  Ann Thorac Surg       Date:  1991-09       Impact factor: 4.330

9.  Effect of metformin on glucose metabolism in the splanchnic bed.

Authors:  C J Bailey; C Wilcock; C Day
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

10.  Hemodynamic changes induced by regular hemodialysis and sequential ultrafiltration hemodialysis: A comparative study.

Authors:  J J Rouby; J Rottembourg; J P Durande; J Y Basset; P Degoulet; P Glaser; M Legrain
Journal:  Kidney Int       Date:  1980-06       Impact factor: 10.612

View more
  1 in total

1.  The Association between Metformin Therapy and Lactic Acidosis.

Authors:  Isabelle H S Kuan; Ruth L Savage; Stephen B Duffull; Robert J Walker; Daniel F B Wright
Journal:  Drug Saf       Date:  2019-12       Impact factor: 5.606

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.