Literature DB >> 23263789

Finding a job for dichloroacetate.

Friedrich C Luft1.   

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Year:  2013        PMID： 23263789     DOI： 10.1007/s00109-012-0989-6

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


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  13 in total

1.  A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

Authors:  Sébastien Bonnet; Stephen L Archer; Joan Allalunis-Turner; Alois Haromy; Christian Beaulieu; Richard Thompson; Christopher T Lee; Gary D Lopaschuk; Lakshmi Puttagunta; Sandra Bonnet; Gwyneth Harry; Kyoko Hashimoto; Christopher J Porter; Miguel A Andrade; Bernard Thebaud; Evangelos D Michelakis
Journal:  Cancer Cell       Date:  2007-01       Impact factor: 31.743

2.  Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.

Authors:  M M Bowker-Kinley; W I Davis; P Wu; R A Harris; K M Popov
Journal:  Biochem J       Date:  1998-01-01       Impact factor: 3.857

3.  Dichloroacetate in the treatment of lactic acidosis.

Authors:  P W Stacpoole; A C Lorenz; R G Thomas; E M Harman
Journal:  Ann Intern Med       Date:  1988-01       Impact factor: 25.391

4.  The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse.

Authors:  A B DeAngelo; F B Daniel; J A Stober; G R Olson
Journal:  Fundam Appl Toxicol       Date:  1991-02

Review 5.  A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension.

Authors:  Jalees Rehman; Stephen L Archer
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

Review 6.  The pharmacology of dichloroacetate.

Authors:  P W Stacpoole
Journal:  Metabolism       Date:  1989-11       Impact factor: 8.694

7.  Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.

Authors:  Peter W Stacpoole; Douglas S Kerr; Carie Barnes; S Terri Bunch; Paul R Carney; Eileen M Fennell; Natalia M Felitsyn; Robin L Gilmore; Melvin Greer; George N Henderson; Alan D Hutson; Richard E Neiberger; Ralph G O'Brien; Leigh Ann Perkins; Ronald G Quisling; Albert L Shroads; Jonathan J Shuster; Janet H Silverstein; Douglas W Theriaque; Edward Valenstein
Journal:  Pediatrics       Date:  2006-05       Impact factor: 7.124

8.  FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.

Authors:  Lin Piao; Vaninder K Sidhu; Yong-Hu Fang; John J Ryan; Kishan S Parikh; Zhigang Hong; Peter T Toth; Erik Morrow; Shelby Kutty; Gary D Lopaschuk; Stephen L Archer
Journal:  J Mol Med (Berl)       Date:  2012-12-18       Impact factor: 4.599

9.  The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

Authors:  Lin Piao; Yong-Hu Fang; Virgilio J J Cadete; Christian Wietholt; Dalia Urboniene; Peter T Toth; Glenn Marsboom; Hannah J Zhang; Idith Haber; Jalees Rehman; Gary D Lopaschuk; Stephen L Archer
Journal:  J Mol Med (Berl)       Date:  2009-12-01       Impact factor: 4.599

10.  The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Authors:  Heather R Christofk; Matthew G Vander Heiden; Marian H Harris; Arvind Ramanathan; Robert E Gerszten; Ru Wei; Mark D Fleming; Stuart L Schreiber; Lewis C Cantley
Journal:  Nature       Date:  2008-03-13       Impact factor: 49.962
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