Literature DB >> 23263543

Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.

Tamás Tábi1, Eva Szökő, Anita Mérey, Veronika Tóth, Péter Mátyus, Klára Gyires.   

Abstract

SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.

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Year:  2012        PMID： 23263543     DOI： 10.1007/s00702-012-0961-1

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  13 in total

1.  A cell surface amine oxidase directly controls lymphocyte migration.

Authors:  M Salmi; G G Yegutkin; R Lehvonen; K Koskinen; T Salminen; S Jalkanen
Journal:  Immunity       Date:  2001-03       Impact factor: 31.745

2.  In vivo detection of vascular adhesion protein-1 in experimental inflammation.

Authors:  K Jaakkola; T Nikula; R Holopainen; T Vähäsilta; M T Matikainen; M L Laukkanen; R Huupponen; L Halkola; L Nieminen; J Hiltunen; S Parviainen; M R Clark; J Knuuti; T Savunen; P Kääpä; L M Voipio-Pulkki; S Jalkanen
Journal:  Am J Pathol       Date:  2000-08       Impact factor: 4.307

3.  Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase.

Authors:  Luisa M Salter-Cid; Eric Wang; Anne M O'Rourke; Andrew Miller; Hongfeng Gao; Li Huang; Arnie Garcia; Matthew D Linnik
Journal:  J Pharmacol Exp Ther       Date:  2005-08-04       Impact factor: 4.030

4.  Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1).

Authors:  Kaisa Koskinen; Petri J Vainio; David J Smith; Marjo Pihlavisto; Seppo Ylä-Herttuala; Sirpa Jalkanen; Marko Salmi
Journal:  Blood       Date:  2004-01-15       Impact factor: 22.113

5.  Lymphocyte binding to vascular endothelium in inflamed skin revisited: a central role for vascular adhesion protein-1 (VAP-1).

Authors:  A M Arvilommi; M Salmi; K Kalimo; S Jalkanen
Journal:  Eur J Immunol       Date:  1996-04       Impact factor: 5.532

6.  Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate.

Authors:  Elina Kivi; Kati Elima; Kristiina Aalto; Yvonne Nymalm; Kaisa Auvinen; Erkki Koivunen; Diana M Otto; Paul R Crocker; Tiina A Salminen; Marko Salmi; Sirpa Jalkanen
Journal:  Blood       Date:  2009-10-27       Impact factor: 22.113

7.  Origins of serum semicarbazide-sensitive amine oxidase.

Authors:  Craig M Stolen; Gennady G Yegutkin; Riikka Kurkijärvi; Petri Bono; Kari Alitalo; Sirpa Jalkanen
Journal:  Circ Res       Date:  2004-06-03       Impact factor: 17.367

Review 8.  VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation.

Authors:  Sirpa Jalkanen; Marko Salmi
Journal:  Arterioscler Thromb Vasc Biol       Date:  2007-10-25       Impact factor: 8.311

9.  Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes.

Authors:  M Salmi; S Tohka; E L Berg; E C Butcher; S Jalkanen
Journal:  J Exp Med       Date:  1997-08-18       Impact factor: 14.307

10.  Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule.

Authors:  D J Smith; M Salmi; P Bono; J Hellman; T Leu; S Jalkanen
Journal:  J Exp Med       Date:  1998-07-06       Impact factor: 14.307
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  7 in total

Review 1.  Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis.

Authors:  Fatemeh Khodadust; Aiarpi Ezdoglian; Maarten M Steinz; Judy R van Beijnum; Gerben J C Zwezerijnen; Gerrit Jansen; Sander W Tas; Conny J van der Laken
Journal:  Int J Mol Sci       Date:  2022-06-25       Impact factor: 6.208

2.  Prenatal dietary load of Maillard reaction products combined with postnatal Coca-Cola drinking affects metabolic status of female Wistar rats.

Authors:  Radana Gurecká; Ivana Koborová; Katarína Janšáková; Tamás Tábi; Éva Szökő; Veronika Somoza; Katarína Šebeková; Peter Celec
Journal:  Croat Med J       Date:  2015-04       Impact factor: 1.351

3.  Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.

Authors:  Ádám Horváth; Awt Menghis; Bálint Botz; Éva Borbély; Ágnes Kemény; Valéria Tékus; Janka Zsófia Csepregi; Attila Mócsai; Tamás Juhász; Róza Zákány; Dóra Bogdán; Péter Mátyus; Julie Keeble; Erika Pintér; Zsuzsanna Helyes
Journal:  Sci Rep       Date:  2017-01-09       Impact factor: 4.379

4.  Increased atherosclerotic plaque in AOC3 knock-out in ApoE-/- mice and characterization of AOC3 in atherosclerotic human coronary arteries.

Authors:  Anna Filip; Soraya Taleb; Rümeyza Bascetin; Mohammad Jahangiri; Matthieu Bardin; Cindy Lerognon; Bruno Fève; Patrick Lacolley; Sirpa Jalkanen; Nathalie Mercier
Journal:  Front Cardiovasc Med       Date:  2022-09-13

Review 5.  Human Copper-Containing Amine Oxidases in Drug Design and Development.

Authors:  Serhii Vakal; Sirpa Jalkanen; Käthe M Dahlström; Tiina A Salminen
Journal:  Molecules       Date:  2020-03-12       Impact factor: 4.411

6.  Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1.

Authors:  Ryo Kubota; Michael J Reid; Kuo Lee Lieu; Mark Orme; Christine Diamond; Niklas Tulberg; Susan H Henry
Journal:  Mediators Inflamm       Date:  2020-01-20       Impact factor: 4.711

7.  Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain.

Authors:  Ádám István Horváth; Nikolett Szentes; Valéria Tékus; Maja Payrits; Éva Szőke; Emőke Oláh; András Garami; Eszter Fliszár-Nyúl; Miklós Poór; Cecília Sár; Tamás Kálai; Szilárd Pál; Krisztina Percze; Éva Nagyné Scholz; Tamás Mészáros; Blanka Tóth; Péter Mátyus; Zsuzsanna Helyes
Journal:  Biomedicines       Date:  2021-06-29
  7 in total

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