| Literature DB >> 23262266 |
Shu Wang1, Jun Li, Jian Sun, Ke-wu Zeng, Jing-rong Cui, Yong Jiang, Peng-fei Tu.
Abstract
An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00μM.Entities:
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Year: 2012 PMID： 23262266 DOI： 10.1016/j.fitote.2012.12.005
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882