| Literature DB >> 23260352 |
Claire-Lise Ciana1, Romain Siegrist, Hamed Aissaoui, Léo Marx, Sophie Racine, Solange Meyer, Christoph Binkert, Ruben de Kanter, Christoph Fischli, Sergio Wittlin, Christoph Boss.
Abstract
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial phramacophore with the known Mannich base pharmacophore of amodiaquine (57) resulted in promising in vivo active novel derivatives.Entities:
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Year: 2012 PMID： 23260352 DOI： 10.1016/j.bmcl.2012.11.118
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823