| Literature DB >> 23259690 |
Michael Dieckmann1, Dirk Menche.
Abstract
A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate β-hydroxy-ketone. The sequence proceeds with excellent anti-selectivities and enables the rapid construction of complex polyketide fragments.Entities:
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Year: 2012 PMID： 23259690 DOI： 10.1021/ol3033303
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005