| Literature DB >> 23258410 |
Guojie Zhang1, Christopher Cowled, Zhengli Shi, Zhiyong Huang, Kimberly A Bishop-Lilly, Xiaodong Fang, James W Wynne, Zhiqiang Xiong, Michelle L Baker, Wei Zhao, Mary Tachedjian, Yabing Zhu, Peng Zhou, Xuanting Jiang, Justin Ng, Lan Yang, Lijun Wu, Jin Xiao, Yue Feng, Yuanxin Chen, Xiaoqing Sun, Yong Zhang, Glenn A Marsh, Gary Crameri, Christopher C Broder, Kenneth G Frey, Lin-Fa Wang, Jun Wang.
Abstract
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.Entities:
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Year: 2012 PMID： 23258410 PMCID： PMC8782153 DOI： 10.1126/science.1230835
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728