UNLABELLED: Osteoarthritis (OA) is a common joint disorder affecting circa 2% of the population. OBJECTIVES: It has been suggested that secretion of vascular endothelial growth factor (VEGF) could play a role in the chain of events leading to OA. METHODS: In the present study, healthy mice were injected intra-articularly with VEGF. RESULTS: Shortly after the administration of VEGF, synovial hyperplasia, increased calcification of the articular cartilage and bone sclerosis were observed. Consequently, cartilage degradation characteristic of OA was found. These changes were seen to a lesser degree in the opposite knees of VEGF-injected mice and did not occur in the control mice. CONCLUSIONS: The findings suggest an active role of VEGF in the pathogenesis of OA and render support to a possible role for subchondral bone sclerosis in the pathogenesis of cartilage degradation.
UNLABELLED: Osteoarthritis (OA) is a common joint disorder affecting circa 2% of the population. OBJECTIVES: It has been suggested that secretion of vascular endothelial growth factor (VEGF) could play a role in the chain of events leading to OA. METHODS: In the present study, healthy mice were injected intra-articularly with VEGF. RESULTS: Shortly after the administration of VEGF, synovial hyperplasia, increased calcification of the articular cartilage and bone sclerosis were observed. Consequently, cartilage degradation characteristic of OA was found. These changes were seen to a lesser degree in the opposite knees of VEGF-injected mice and did not occur in the control mice. CONCLUSIONS: The findings suggest an active role of VEGF in the pathogenesis of OA and render support to a possible role for subchondral bone sclerosis in the pathogenesis of cartilage degradation.
Authors: John L Hamilton; Masashi Nagao; Brett R Levine; Di Chen; Bjorn R Olsen; Hee-Jeong Im Journal: J Bone Miner Res Date: 2016-04-08 Impact factor: 6.741
Authors: Era Jain; Nobuaki Chinzei; Alexandra Blanco; Natasha Case; Linda J Sandell; Scott Sell; Muhammad Farooq Rai; Silviya P Zustiak Journal: J Orthop Res Date: 2019-07-22 Impact factor: 3.494
Authors: Stine Mandrup Andreassen; Lise C Berg; Søren Saxmose Nielsen; Annemarie T Kristensen; Stine Jacobsen Journal: BMC Vet Res Date: 2015-06-27 Impact factor: 2.741
Authors: Anika I Tsuchida; Michiel Beekhuizen; Marieke C 't Hart; Timothy R D J Radstake; Wouter J A Dhert; Daniel B F Saris; Gerjo J V M van Osch; Laura B Creemers Journal: Arthritis Res Ther Date: 2014-09-26 Impact factor: 5.156