Literature DB >> 23254563

In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using ¹H Magnetic Resonance Spectroscopy.

Cristina Cudalbu1.   

Abstract

Hepatic encephalopathy (HE) is a common and severe neuropsychiatric complication present in acute and chronic liver disease. The unique advantages of high field (1)H MRS provide a method for assessing pathogenic mechanism, diagnosis and monitoring of HE, as well as for treatment assessment or recovery after liver transplantation, in a reproducible and reliable non-invasive way. The purpose of the present review is to present some new features of in vivo proton Magnetic Resonance Spectroscopy ((1)H MRS) at high magnetic fields combined with some basic requirements for reliable metabolic profiling. Finally, in vivo applications of (1)H MRS in different HE animal models are presented.

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Year:  2012        PMID： 23254563     DOI： 10.1007/s11011-012-9368-9

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  51 in total

Review 1.  Handling macromolecule signals in the quantification of the neurochemical profile.

Authors:  Cristina Cudalbu; Vladimir Mlynárik; Rolf Gruetter
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

Review 2.  MR imaging findings in hepatic encephalopathy.

Authors:  A Rovira; J Alonso; J Córdoba
Journal:  AJNR Am J Neuroradiol       Date:  2008-06-26       Impact factor: 3.825

3.  Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine.

Authors:  Renata Leke; Lasse K Bak; Malene Anker; Torun M Melø; Michael Sørensen; Susanne Keiding; Hendrik Vilstrup; Peter Ott; Luis V Portela; Ursula Sonnewald; Arne Schousboe; Helle S Waagepetersen
Journal:  Neurotox Res       Date:  2010-05-18       Impact factor: 3.911

4.  High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo.

Authors:  Robin A de Graaf; Peter B Brown; Scott McIntyre; Terence W Nixon; Kevin L Behar; Douglas L Rothman
Journal:  Magn Reson Med       Date:  2006-08       Impact factor: 4.668

Review 5.  13N as a tracer for studying glutamate metabolism.

Authors:  Arthur J L Cooper
Journal:  Neurochem Int       Date:  2010-11-23       Impact factor: 3.921

6.  Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis.

Authors:  J Córdoba; J Gottstein; A T Blei
Journal:  J Hepatol       Date:  1998-10       Impact factor: 25.083

7.  Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure.

Authors:  Laia Chavarria; Marc Oria; Jordi Romero-Gimenez; Juli Alonso; Silvia Lope-Piedrafita; Juan Cordoba
Journal:  Gastroenterology       Date:  2009-10-17       Impact factor: 22.682

8.  Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors.

Authors:  Omar Cauli; Pilar López-Larrubia; Tiago B Rodrigues; Sebastián Cerdán; Vicente Felipo
Journal:  J Neurochem       Date:  2007-08-28       Impact factor: 5.372

9.  Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla.

Authors:  Cristina Cudalbu; Vladimír Mlynárik; Lijing Xin; Rolf Gruetter
Journal:  Magn Reson Med       Date:  2009-10       Impact factor: 4.668

10.  Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation.

Authors:  D K Bosman; N E Deutz; A A De Graaf; R W vd Hulst; H M Van Eijk; W M Bovée; M A Maas; G G Jörning; R A Chamuleau
Journal:  Hepatology       Date:  1990-08       Impact factor: 17.425
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  12 in total

Review 1.  Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Authors:  Chantal Bémeur; Cristina Cudalbu; Gitte Dam; Alexander S Thrane; Arthur J L Cooper; Christopher F Rose
Journal:  Metab Brain Dis       Date:  2016-06-07       Impact factor: 3.584

2.  In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T.

Authors:  Cristina Cudalbu; Melanie Craveiro; Vladimir Mlynárik; Juliane Bremer; Adriano Aguzzi; Rolf Gruetter
Journal:  Neurochem Res       Date:  2015-07-23       Impact factor: 3.996

Review 3.  Hyperammonemia in Inherited Metabolic Diseases.

Authors:  Graziela Schmitt Ribas; Franciele Fátima Lopes; Marion Deon; Carmen Regla Vargas
Journal:  Cell Mol Neurobiol       Date:  2021-10-19       Impact factor: 4.231

4.  1H and 31P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism.

Authors:  Veronika Rackayova; Olivier Braissant; Valérie A McLin; Corina Berset; Bernard Lanz; Cristina Cudalbu
Journal:  Metab Brain Dis       Date:  2015-08-09       Impact factor: 3.584

5.  Acute Hyperammonemia Induces NMDA-Mediated Hypophosphorylation of Intermediate Filaments Through PP1 and PP2B in Cerebral Cortex of Young Rats.

Authors:  Rônan Vivian Carvalho; Fernanda da Silva Ferreira; Luana Heimfarth; Paula Pierozan; Carolina Fernandes; Regina Pessoa-Pureur
Journal:  Neurotox Res       Date:  2016-03-02       Impact factor: 3.911

6.  Brain Microstructural Correlates of Cognitive Dysfunction in Clinically and Biochemically Normal Hepatitis C Virus Infection.

Authors:  Ajay Kumar; Amar Deep; Rakesh K Gupta; Virendra Atam; Samir Mohindra
Journal:  J Clin Exp Hepatol       Date:  2017-04-04

Review 7.  Ammonia toxicity: from head to toe?

Authors:  Srinivasan Dasarathy; Rajeshwar P Mookerjee; Veronika Rackayova; Vinita Rangroo Thrane; Balasubramaniyan Vairappan; Peter Ott; Christopher F Rose
Journal:  Metab Brain Dis       Date:  2016-12-24       Impact factor: 3.584

8.  Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.

Authors:  Bernard Lanz; Alireza Abaei; Olivier Braissant; In-Young Choi; Cristina Cudalbu; Pierre-Gilles Henry; Rolf Gruetter; Firat Kara; Kejal Kantarci; Phil Lee; Norbert W Lutz; Małgorzata Marjańska; Vladimír Mlynárik; Volker Rasche; Lijing Xin; Julien Valette
Journal:  NMR Biomed       Date:  2020-08-26       Impact factor: 4.478

Review 9.  Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.

Authors:  Natalie M Zahr; Adolf Pfefferbaum
Journal:  Alcohol Res       Date:  2017

10.  Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease.

Authors:  Veronika Rackayova; Olivier Braissant; Anne-Laure Rougemont; Cristina Cudalbu; Valérie A McLin
Journal:  Sci Rep       Date:  2020-05-05       Impact factor: 4.379
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