Literature DB >> 23254420

Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.

Alexander Speer1, Tej B Shrestha, Stefan H Bossmann, Randall J Basaraba, Gregory J Harber, Suzanne M Michalek, Michael Niederweis, Olaf Kutsch, Frank Wolschendorf.   

Abstract

We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.

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Year:  2012        PMID： 23254420      PMCID： PMC3553712          DOI： 10.1128/AAC.01781-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Function and regulation of human copper-transporting ATPases.

Authors:  Svetlana Lutsenko; Natalie L Barnes; Mee Y Bartee; Oleg Y Dmitriev
Journal:  Physiol Rev       Date:  2007-07       Impact factor: 37.312

2.  High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.

Authors:  Subramaniam Ananthan; Ellen R Faaleolea; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Barbara E Laughon; Joseph A Maddry; Alka Mehta; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Nice Shindo; Dustin N Showe; Melinda I Sosa; William J Suling; E Lucile White
Journal:  Tuberculosis (Edinb)       Date:  2009-09-15       Impact factor: 3.131

3.  CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis.

Authors:  Sarah K Ward; Bassam Abomoelak; Elizabeth A Hoye; Howard Steinberg; Adel M Talaat
Journal:  Mol Microbiol       Date:  2010-09       Impact factor: 3.501

4.  Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.

Authors:  Cynthia P W Soon; Paul S Donnelly; Bradley J Turner; Lin W Hung; Peter J Crouch; Nicki A Sherratt; Jiang-Li Tan; Nastasia K-H Lim; Linh Lam; Laura Bica; SinChun Lim; James L Hickey; Julia Morizzi; Andrew Powell; David I Finkelstein; Janetta G Culvenor; Colin L Masters; James Duce; Anthony R White; Kevin J Barnham; Qiao-Xin Li
Journal:  J Biol Chem       Date:  2011-10-27       Impact factor: 5.157

5.  Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.

Authors:  Vasan K Sambandamurthy; Steven C Derrick; Tsungda Hsu; Bing Chen; Michelle H Larsen; Kripa V Jalapathy; Mei Chen; John Kim; Steven A Porcelli; John Chan; Sheldon L Morris; William R Jacobs
Journal:  Vaccine       Date:  2006-06-12       Impact factor: 3.641

6.  Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis.

Authors:  Olga Danilchanka; Claudia Mailaender; Michael Niederweis
Journal:  Antimicrob Agents Chemother       Date:  2008-05-05       Impact factor: 5.191

7.  Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice.

Authors:  Ping Zhang; Jenny Katz; Suzanne M Michalek
Journal:  Mol Immunol       Date:  2008-10-17       Impact factor: 4.407

8.  A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity.

Authors:  Carine White; Jaekwon Lee; Taiho Kambe; Kevin Fritsche; Michael J Petris
Journal:  J Biol Chem       Date:  2009-10-05       Impact factor: 5.157

9.  Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.

Authors:  Sung-Ho Chen; Jen-Kun Lin; Shing-Hwa Liu; Yu-Chih Liang; Shoei-Yn Lin-Shiau
Journal:  Toxicol Sci       Date:  2007-12-04       Impact factor: 4.849

Review 10.  New applications of old metal-binding drugs in the treatment of human cancer.

Authors:  Sara M Schmitt; Michael Frezza; Qing Ping Dou
Journal:  Front Biosci (Schol Ed)       Date:  2012-01-01
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  21 in total

1.  8-Hydroxyquinolines Are Boosting Agents of Copper-Related Toxicity in Mycobacterium tuberculosis.

Authors:  Santosh Shah; Alex G Dalecki; Aruni P Malalasekera; Cameron L Crawford; Suzanne M Michalek; Olaf Kutsch; Jim Sun; Stefan H Bossmann; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureus.

Authors:  Mehri Haeili; Casey Moore; Christopher J C Davis; James B Cochran; Santosh Shah; Tej B Shrestha; Yaofang Zhang; Stefan H Bossmann; William H Benjamin; Olaf Kutsch; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2014-04-21       Impact factor: 5.191

Review 3.  Copper homeostasis in Mycobacterium tuberculosis.

Authors:  Xiaoshan Shi; K Heran Darwin
Journal:  Metallomics       Date:  2015-06       Impact factor: 4.526

4.  Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner.

Authors:  Alex G Dalecki; Mehri Haeili; Santosh Shah; Alexander Speer; Michael Niederweis; Olaf Kutsch; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

5.  Porins increase copper susceptibility of Mycobacterium tuberculosis.

Authors:  Alexander Speer; Jennifer L Rowland; Mehri Haeili; Michael Niederweis; Frank Wolschendorf
Journal:  J Bacteriol       Date:  2013-09-06       Impact factor: 3.490

6.  A Macrophage Infection Model to Predict Drug Efficacy Against Mycobacterium Tuberculosis.

Authors:  Kaitlyn Schaaf; Virginia Hayley; Alexander Speer; Frank Wolschendorf; Michael Niederweis; Olaf Kutsch; Jim Sun
Journal:  Assay Drug Dev Technol       Date:  2016-06-21       Impact factor: 1.738

7.  Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.

Authors:  Karrera Y Djoko; Maud E S Achard; Minh-Duy Phan; Alvin W Lo; Manfredi Miraula; Sasiprapa Prombhul; Steven J Hancock; Kate M Peters; Hanna E Sidjabat; Patrick N Harris; Nataša Mitić; Timothy R Walsh; Gregory J Anderson; William M Shafer; David L Paterson; Gerhard Schenk; Alastair G McEwan; Mark A Schembri
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

8.  Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.

Authors:  Jacqueline M Zaengle-Barone; Abigail C Jackson; David M Besse; Bradford Becken; Mehreen Arshad; Patrick C Seed; Katherine J Franz
Journal:  ACS Infect Dis       Date:  2018-03-26       Impact factor: 5.084

9.  A multicopper oxidase is required for copper resistance in Mycobacterium tuberculosis.

Authors:  Jennifer L Rowland; Michael Niederweis
Journal:  J Bacteriol       Date:  2013-06-14       Impact factor: 3.490

Review 10.  Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?

Authors:  K Heran Darwin
Journal:  J Biol Chem       Date:  2015-06-08       Impact factor: 5.157
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