Literature DB >> 23253000

Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan.

G W Don1, F Joseph, D S Celermajer, T J Corte.   

Abstract

A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on a phosphodiesterase-5 inhibitor.
© 2012 The Authors; Internal Medicine Journal © 2012 Royal Australasian College of Physicians.

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Year:  2012        PMID: 23253000     DOI: 10.1111/imj.12007

Source DB:  PubMed          Journal:  Intern Med J        ISSN: 1444-0903            Impact factor:   2.048


  6 in total

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