Literature DB >> 23250475

Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids.

Dnyaneshwar B Gophane1, Snorri Th Sigurdsson.   

Abstract

Nucleosides spin-labelled with isoindoline-derived benzimidazole ((Im)U) and benzoxazole ((Ox)U) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but (Im)U was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.

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Year:  2012        PMID： 23250475     DOI： 10.1039/c2cc36389e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy.

Authors:  Dnyaneshwar B Gophane; Snorri Th Sigurdsson
Journal:  Beilstein J Org Chem       Date:  2015-02-09       Impact factor: 2.883

2.  Phosphoramidite building blocks with protected nitroxides for the synthesis of spin-labeled DNA and RNA.

Authors:  Timo Weinrich; Eva A Jaumann; Ute M Scheffer; Thomas F Prisner; Michael W Göbel
Journal:  Beilstein J Org Chem       Date:  2018-06-26       Impact factor: 2.883

3.  Isoindoline-Based Nitroxides as Bioresistant Spin Labels for Protein Labeling through Cysteines and Alkyne-Bearing Noncanonical Amino Acids.

Authors:  Theresa Sophie Braun; Pia Widder; Uwe Osswald; Lina Groß; Lara Williams; Moritz Schmidt; Irina Helmle; Daniel Summerer; Malte Drescher
Journal:  Chembiochem       Date:  2019-12-06       Impact factor: 3.164

4.  Compaction of RNA Duplexes in the Cell*.

Authors:  Alberto Collauto; Sören von Bülow; Dnyaneshwar B Gophane; Subham Saha; Lukas S Stelzl; Gerhard Hummer; Snorri T Sigurdsson; Thomas F Prisner
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-13       Impact factor: 15.336
  4 in total

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