BACKGROUND: We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study. METHODS: Correlates of GGT fractions were assessed by multivariable regression analysis in 3203 individuals [47% men, mean age (SD): 59 (10) years]. GGT fractions reference values were established by empirical quantile analysis in a reference group of 432 healthy subjects [45% men, 57 (10) years]. RESULTS: Fractional GGT levels were higher in men than in women (P<0.0001). In both sexes, fractions were associated with: triglycerides were associated with b-GGT, alcohol consumption with m-, s- and f-GGT. C-reactive protein with m- and s-GGT, while plasminogen activator inhibitor-1 with b- and f-GGT. Body mass index, blood pressure, glucose and triglycerides correlated with b- and f-GGT. In comparison with the reference group [b-GGT/s-GGT median (Q1-Q3): 0.51 (0.35-0.79)U/L], subjects affected by cardiovascular disease or diabetes showed no change of b/s ratio [0.52 (0.34-0.79)U/L, 0.57 (0.40-0.83)U/L, respectively]. The b/s ratio was higher in presence of metabolic syndrome [0.61 (0.42-0.87)U/L, P<0.0001], while lower in heavy alcohol consumers [0.41 (0.28-0.64)U/L, P<0.0001]. CONCLUSIONS: Metabolic and cardiovascular risk markers are important correlates of GGT fractions, in particular of b-GGT.
BACKGROUND: We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study. METHODS: Correlates of GGT fractions were assessed by multivariable regression analysis in 3203 individuals [47% men, mean age (SD): 59 (10) years]. GGT fractions reference values were established by empirical quantile analysis in a reference group of 432 healthy subjects [45% men, 57 (10) years]. RESULTS: Fractional GGT levels were higher in men than in women (P<0.0001). In both sexes, fractions were associated with: triglycerides were associated with b-GGT, alcohol consumption with m-, s- and f-GGT. C-reactive protein with m- and s-GGT, while plasminogen activator inhibitor-1 with b- and f-GGT. Body mass index, blood pressure, glucose and triglycerides correlated with b- and f-GGT. In comparison with the reference group [b-GGT/s-GGT median (Q1-Q3): 0.51 (0.35-0.79)U/L], subjects affected by cardiovascular disease or diabetes showed no change of b/s ratio [0.52 (0.34-0.79)U/L, 0.57 (0.40-0.83)U/L, respectively]. The b/s ratio was higher in presence of metabolic syndrome [0.61 (0.42-0.87)U/L, P<0.0001], while lower in heavy alcohol consumers [0.41 (0.28-0.64)U/L, P<0.0001]. CONCLUSIONS: Metabolic and cardiovascular risk markers are important correlates of GGT fractions, in particular of b-GGT.
Authors: M Emdin; C Passino; C Michelassi; F Titta; A L'abbate; L Donato; A Pompella; A Paolicchi Journal: Eur Heart J Date: 2001-10 Impact factor: 29.983
Authors: Alexander M Strasak; Cecily C Kelleher; Jochen Klenk; Larry J Brant; Elfriede Ruttmann; Kilian Rapp; Hans Concin; Günter Diem; Karl P Pfeiffer; Hanno Ulmer Journal: Arterioscler Thromb Vasc Biol Date: 2008-07-10 Impact factor: 8.311
Authors: Abigail Fraser; Ross Harris; Naveed Sattar; Shah Ebrahim; George Davey Smith; Debbie A Lawlor Journal: Diabetes Care Date: 2009-01-08 Impact factor: 17.152
Authors: Jenny H D A van Beek; Marleen H M de Moor; Lot M Geels; Michel R T Sinke; Eco J C de Geus; Gitta H Lubke; Cornelis Kluft; Jacoline Neuteboom; Jacqueline M Vink; Gonneke Willemsen; Dorret I Boomsma Journal: Drug Alcohol Depend Date: 2013-09-27 Impact factor: 4.492
Authors: Michael Schivo; Alexander A Aksenov; Laura C Yeates; Alberto Pasamontes; Cristina E Davis Journal: Front Endocrinol (Lausanne) Date: 2013-11-25 Impact factor: 5.555