BACKGROUND: Deep brain stimulation has been investigated in the past decade as a viable intervention for treatment-resistant depression. METHODS: Several anatomic targets have been tested, with the most extensive published experience found for the subcallosal cingulate (SCC) white matter. RESULTS: This article reviews the current state of clinical research of SCC deep brain stimulation for treatment-resistant depression, including an overview of the rationale for targeting SCC, practical considerations for subject recruitment and evaluation, surgical planning, and stimulation parameters. CONCLUSION: Clinical management of patients in the initial and long-term naturalistic phases of treatment, including the potential role for psychotherapeutic rehabilitation, is discussed.
BACKGROUND: Deep brain stimulation has been investigated in the past decade as a viable intervention for treatment-resistant depression. METHODS: Several anatomic targets have been tested, with the most extensive published experience found for the subcallosal cingulate (SCC) white matter. RESULTS: This article reviews the current state of clinical research of SCC deep brain stimulation for treatment-resistant depression, including an overview of the rationale for targeting SCC, practical considerations for subject recruitment and evaluation, surgical planning, and stimulation parameters. CONCLUSION: Clinical management of patients in the initial and long-term naturalistic phases of treatment, including the potential role for psychotherapeutic rehabilitation, is discussed.
Authors: Zoe Samara; Elisabeth A T Evers; Frenk Peeters; Harry B M Uylings; Grazyna Rajkowska; Johannes G Ramaekers; Peter Stiers Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-02-02
Authors: Michelle Lee; Toby R Manders; Sarah E Eberle; Chen Su; James D'amour; Runtao Yang; Hau Yueh Lin; Karl Deisseroth; Robert C Froemke; Jing Wang Journal: J Neurosci Date: 2015-04-01 Impact factor: 6.167
Authors: Thomas E Schlaepfer; Bettina H Bewernick; Sarah Kayser; Rene Hurlemann; Volker A Coenen Journal: Neuropsychopharmacology Date: 2014-02-11 Impact factor: 7.853
Authors: W-J Neumann; J Huebl; C Brücke; L Gabriëls; M Bajbouj; A Merkl; G-H Schneider; B Nuttin; P Brown; A A Kühn Journal: Mol Psychiatry Date: 2014-02-11 Impact factor: 15.992