OBJECTIVES: A primary dose of the European Union (EU)-licensed meningococcal A, C, W-135, and Y tetanus toxoid conjugate vaccine (MenACWY-TT) was immunogenic and well-tolerated in subjects aged 15-19 years. This study assessed antibody persistence at 3.5 years after vaccination with a MenACWY-TT or a tetravalent ACWY polysaccharide vaccine (MenPS, control). METHODS: In the original study, participants were randomized to receive a single dose of MenACWY-TT or MenPS. Serum bactericidal activity using rabbit serum as exogenous complement source was evaluated up to 42 months post-vaccination. RESULTS: At 42 months post-vaccination with MenACWY-TT (n = 19) or MenPS (n = 17), all subjects in each group had serum bactericidal activity titers ≥1:8 against all serogroups, except for two subjects in the MenPS group against serogroup C. Geometricmean antibody titers were higher than pre-vaccination levels at all post-vaccination time-points in both groups, and were significantly higher in the MenACWY-TT group versus the MenPS group for serogroup W-135 at month 42 (exploratory analysis). CONCLUSIONS: These results indicate that seroprotection following primary vaccination with MenACWY-TT extends more than 3 years. Ongoing persistence data are required to understand the duration of protection following vaccination and to guide decisions on the need for future booster doses.
RCT Entities:
OBJECTIVES: A primary dose of the European Union (EU)-licensed meningococcal A, C, W-135, and Y tetanus toxoid conjugate vaccine (MenACWY-TT) was immunogenic and well-tolerated in subjects aged 15-19 years. This study assessed antibody persistence at 3.5 years after vaccination with a MenACWY-TT or a tetravalent ACWY polysaccharide vaccine (MenPS, control). METHODS: In the original study, participants were randomized to receive a single dose of MenACWY-TT or MenPS. Serum bactericidal activity using rabbit serum as exogenous complement source was evaluated up to 42 months post-vaccination. RESULTS: At 42 months post-vaccination with MenACWY-TT (n = 19) or MenPS (n = 17), all subjects in each group had serum bactericidal activity titers ≥1:8 against all serogroups, except for two subjects in the MenPS group against serogroup C. Geometric mean antibody titers were higher than pre-vaccination levels at all post-vaccination time-points in both groups, and were significantly higher in the MenACWY-TT group versus the MenPS group for serogroup W-135 at month 42 (exploratory analysis). CONCLUSIONS: These results indicate that seroprotection following primary vaccination with MenACWY-TT extends more than 3 years. Ongoing persistence data are required to understand the duration of protection following vaccination and to guide decisions on the need for future booster doses.
Authors: Margaret C Bash; Freyja Lynn; Brian Mocca; Ray Borrow; Helen Findlow; Musa Hassan-King; Marie-Pierre Preziosi; Olubukola Idoko; Samba Sow; Prasad Kulkarni; F Marc Laforce Journal: Clin Vaccine Immunol Date: 2014-03-26
Authors: Charissa Fay Corazon Borja-Tabora; Paula Peyrani; Chris Webber; Marie Van der Wielen; Brigitte Cheuvart; Nathalie De Schrevel; Veronique Bianco; Emmanuel Aris; Mark Cutler; Ping Li; John L Perez Journal: BMC Infect Dis Date: 2020-06-18 Impact factor: 3.090
Authors: Beatriz Quiambao; Paula Peyrani; Ping Li; Mark W Cutler; Marie Van Der Wielen; John L Perez; Chris Webber Journal: Hum Vaccin Immunother Date: 2020-05-13 Impact factor: 3.452