OBJECTIVE:Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease, yet effective therapeutic approaches are lacking. This study aimed to determine the effects of application of berberine gelatin in the treatment of minor RAS (MiRAS). METHODS: A randomized, double-blind, placebo-controlled, clinical trial was performed. The gelatin containing berberine (5 mg/g) or vehicle only was applied 4 times per day for 5 days. Clinical evaluation included pain level, size, erythema, and exudation of certain ulcers on days 1, 2, 4, and 6. RESULTS: A total of 84 subjects fulfilled the study without obvious side effects. Berberine gelatin treatment reduced the ulcer pain score compared with placebo gelatin (P < 0.05). Ulcer size was significantly reduced (P < 0.05) and lower erythema (P < 0.05) and exudation (P < 0.05) levels were associated with berberine treatment. CONCLUSIONS:Berberine gelatin may be a safe and effective treatment for MiRAS.
RCT Entities:
OBJECTIVE: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease, yet effective therapeutic approaches are lacking. This study aimed to determine the effects of application of berberine gelatin in the treatment of minor RAS (MiRAS). METHODS: A randomized, double-blind, placebo-controlled, clinical trial was performed. The gelatin containing berberine (5 mg/g) or vehicle only was applied 4 times per day for 5 days. Clinical evaluation included pain level, size, erythema, and exudation of certain ulcers on days 1, 2, 4, and 6. RESULTS: A total of 84 subjects fulfilled the study without obvious side effects. Berberine gelatin treatment reduced the ulcer pain score compared with placebo gelatin (P < 0.05). Ulcer size was significantly reduced (P < 0.05) and lower erythema (P < 0.05) and exudation (P < 0.05) levels were associated with berberine treatment. CONCLUSIONS:Berberine gelatin may be a safe and effective treatment for MiRAS.
Authors: Schilin D Wen; Eulàlia Sans-Serramitjana; Javiera F Santander; Mariela R Sánchez; Paulina Salazar-Aguilar; Andrea B Zepeda; Susana I Alvarado; Ignacia B Miranda Journal: J Clin Exp Dent Date: 2021-10-01
Authors: Sabrina Saurin; Myriam Meineck; Gerhard Erkel; Till Opatz; Julia Weinmann-Menke; Andrea Pautz Journal: Pharmaceuticals (Basel) Date: 2022-04-20
Authors: Yingming Yang; Tao Zhang; Zibo Dong; Yang Wu; Xiao Hong; Tao Hu Journal: Evid Based Complement Alternat Med Date: 2016-11-14 Impact factor: 2.629