| Literature DB >> 23245872 |
D Boubetra1, N Sabaou, A Zitouni, C Bijani, A Lebrihi, F Mathieu.
Abstract
Actinomycete strain SA198, isolated from a Saharan soil sample of Algeria, exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, and phytopathogenic and toxinogenic fungi. The morphological and chemotaxonomic characteristics of the strain were consistent with those of the genus Saccharothrix. Analysis of the 16S rRNA gene sequence of strain SA198 showed a similarity level ranging between 97.2 and 98.8% within Saccharothrix species, S. australiensis being the most closely related. Two new active products were isolated by reverse HPLC using a C18 column. The ultraviolet-visible (UV-VIS), infrared (IR), mass, and (1)H and (14)C nuclear magnetic resonance (NMR) spectra showed that these products were new bioactive compounds. The minimum inhibitory concentrations of these antibiotics showed a strong activity against fungi and moderate activities against Gram-positive and Gram-negative bacteria.Entities:
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Year: 2012 PMID： 23245872 DOI： 10.1016/j.micres.2012.11.005
Source DB: PubMed Journal: Microbiol Res ISSN： 0944-5013 Impact factor: 5.415