| Literature DB >> 23244576 |
Tiago R Figueira1, Mario H Barros, Anamaria A Camargo, Roger F Castilho, Julio C B Ferreira, Alicia J Kowaltowski, Francis E Sluse, Nadja C Souza-Pinto, Anibal E Vercesi.
Abstract
Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and damaging pathways in different tissues. In addition, mitochondria are an important target of reactive oxygen and nitrogen species. Here, we discuss basic mechanisms of mitochondrial oxidant generation and removal and the main factors affecting mitochondrial redox balance. We also discuss the interaction between mitochondrial reactive oxygen and nitrogen species, and the involvement of these oxidants in mitochondrial diseases, cancer, neurological, and cardiovascular disorders.Entities:
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Year: 2013 PMID: 23244576 DOI: 10.1089/ars.2012.4729
Source DB: PubMed Journal: Antioxid Redox Signal ISSN: 1523-0864 Impact factor: 8.401