Sheng-Ming Yi1, Gui-Yuan Li. 1. Department of Oncology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Abstract
BACKGROUND/AIMS: Glutathione S-transferase T1 (GSTT1), a phase-II enzyme, plays an important role in detoxification of carcinogen electrophiles. Many studies have investigated the association between GSTT1 polymorphism and esophageal cancer risk in Asian populations, but its actual impact is not clear owing to apparent inconsistencies among those studies. Thus, a meta-analysis was performed to explore the effect of GSTT1 polymorphism on the risk of developing esophageal cancer. METHODS: A literature search of PubMed, Embase, and Wanfang databases up to August 2012 was conducted and 15 eligible papers were finally selected, involving a total of 1,626 esophageal cancer cases and 2,216 controls. We used the pooled odds ratio (OR) with its corresponding 95% confidence interval (95%CI) to estimate the association of GSTT1 polymorphism with esophageal cancer risk. Subgroup analyses and sensitivity analyses were performed to further identify the association. RESULTS: Meta-analysis of total studies showed the null genotype of GSTT1 was significantly associated with an increased risk of esophageal cancer in Asians (OR=1.26, 95%CI=1.05-1.52, POR=0.015, I2=42.7%). Subgroup analyses by sample size and countries also identified a significant association. Sensitivity analysis further demonstrated a relationship of GSTT1 polymorphism to esophageal cancer risk in Asians. CONCLUSIONS: The present meta-analysis of available data showed a significant association between the null genotype of GSTT1 and an increased risk of esophageal cancer in Asians, particularly in China.
BACKGROUND/AIMS: Glutathione S-transferase T1 (GSTT1), a phase-II enzyme, plays an important role in detoxification of carcinogen electrophiles. Many studies have investigated the association between GSTT1 polymorphism and esophageal cancer risk in Asian populations, but its actual impact is not clear owing to apparent inconsistencies among those studies. Thus, a meta-analysis was performed to explore the effect of GSTT1 polymorphism on the risk of developing esophageal cancer. METHODS: A literature search of PubMed, Embase, and Wanfang databases up to August 2012 was conducted and 15 eligible papers were finally selected, involving a total of 1,626 esophageal cancer cases and 2,216 controls. We used the pooled odds ratio (OR) with its corresponding 95% confidence interval (95%CI) to estimate the association of GSTT1 polymorphism with esophageal cancer risk. Subgroup analyses and sensitivity analyses were performed to further identify the association. RESULTS: Meta-analysis of total studies showed the null genotype of GSTT1 was significantly associated with an increased risk of esophageal cancer in Asians (OR=1.26, 95%CI=1.05-1.52, POR=0.015, I2=42.7%). Subgroup analyses by sample size and countries also identified a significant association. Sensitivity analysis further demonstrated a relationship of GSTT1 polymorphism to esophageal cancer risk in Asians. CONCLUSIONS: The present meta-analysis of available data showed a significant association between the null genotype of GSTT1 and an increased risk of esophageal cancer in Asians, particularly in China.
Authors: Muzamil Ashraf Makhdoomi; Idrees Ayoub Shah; Gulzar Ahmad Bhat; Shajrul Amin; Mohd Maqbool Lone; Farhad Islami; Nazir Ahmad Dar Journal: Tumour Biol Date: 2014-11-29
Authors: Daysha Ferrer-Torres; Derek J Nancarrow; Hannah Steinberg; Zhuwen Wang; Rork Kuick; Katherine M Weh; Ryan E Mills; Dipankar Ray; Paramita Ray; Jules Lin; Andrew C Chang; Rishindra M Reddy; Mark B Orringer; Marcia I Canto; Nicholas J Shaheen; Laura A Kresty; Amitabh Chak; Thomas D Wang; Joel H Rubenstein; David G Beer Journal: Gastroenterology Date: 2018-12-19 Impact factor: 22.682