Literature DB >> 23243614

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer.

Harri Sihto1, Heikki Joensuu.   

Abstract

An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boosting host immune functions might constitute a new approach for the treatment of MCC.

Entities:  

Year:  2012        PMID： 23243614      PMCID： PMC3518523          DOI： 10.4161/onci.21120

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Activation of PI3K signaling in Merkel cell carcinoma.

Authors:  Valentina Nardi; Youngchul Song; Juan A Santamaria-Barria; Arjola K Cosper; Quynh Lam; Anthony C Faber; Genevieve M Boland; Beow Y Yeap; Kristin Bergethon; Vanessa L Scialabba; Hensin Tsao; Jeffrey Settleman; David P Ryan; Darrell R Borger; Atul K Bhan; Mai P Hoang; Anthony J Iafrate; James C Cusack; Jeffrey A Engelman; Dora Dias-Santagata
Journal:  Clin Cancer Res       Date:  2012-01-18       Impact factor: 12.531

Review 2.  Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.

Authors:  Shailender Bhatia; Olga Afanasiev; Paul Nghiem
Journal:  Curr Oncol Rep       Date:  2011-12       Impact factor: 5.075

3.  Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.

Authors:  Roland Houben; Masahiro Shuda; Rita Weinkam; David Schrama; Huichen Feng; Yuan Chang; Patrick S Moore; Jürgen C Becker
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

4.  Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.

Authors:  Harri Sihto; Heli Kukko; Virve Koljonen; Risto Sankila; Tom Böhling; Heikki Joensuu
Journal:  Clin Cancer Res       Date:  2011-06-03       Impact factor: 12.531

5.  Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival.

Authors:  J Girschik; K Thorn; T W Beer; P J Heenan; L Fritschi
Journal:  Br J Dermatol       Date:  2011-09-29       Impact factor: 9.302

6.  Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study.

Authors:  Harri Sihto; Tom Böhling; Heli Kavola; Virve Koljonen; Marko Salmi; Sirpa Jalkanen; Heikki Joensuu
Journal:  Clin Cancer Res       Date:  2012-03-30       Impact factor: 12.531

7.  Restoring function in exhausted CD8 T cells during chronic viral infection.

Authors:  Daniel L Barber; E John Wherry; David Masopust; Baogong Zhu; James P Allison; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Journal:  Nature       Date:  2005-12-28       Impact factor: 49.962

8.  Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.

Authors:  Kelly G Paulson; Joseph J Carter; Lisa G Johnson; Kevin W Cahill; Jayasri G Iyer; David Schrama; Juergen C Becker; Margaret M Madeleine; Paul Nghiem; Denise A Galloway
Journal:  Cancer Res       Date:  2010-10-19       Impact factor: 12.701

9.  Clonal integration of a polyomavirus in human Merkel cell carcinoma.

Authors:  Huichen Feng; Masahiro Shuda; Yuan Chang; Patrick S Moore
Journal:  Science       Date:  2008-01-17       Impact factor: 47.728

10.  Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc.

Authors:  Kelly G Paulson; Bianca D Lemos; Bin Feng; Natalia Jaimes; Pablo F Peñas; Xiaohui Bi; Elizabeth Maher; Lisa Cohen; J Helen Leonard; Scott R Granter; Lynda Chin; Paul Nghiem
Journal:  J Invest Dermatol       Date:  2008-11-20       Impact factor: 8.551
  10 in total
  13 in total

1.  Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma.

Authors:  Natalie J Miller; Shailender Bhatia; Upendra Parvathaneni; Jayasri G Iyer; Paul Nghiem
Journal:  Curr Treat Options Oncol       Date:  2013-06

2.  Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.

Authors:  Natalie J Miller; Candice D Church; Lichun Dong; David Crispin; Matthew P Fitzgibbon; Kristina Lachance; Lichen Jing; Michi Shinohara; Ioannis Gavvovidis; Gerald Willimsky; Martin McIntosh; Thomas Blankenstein; David M Koelle; Paul Nghiem
Journal:  Cancer Immunol Res       Date:  2017-01-16       Impact factor: 11.151

3.  Prognostic Impact of MCPyV and TIL Subtyping in Merkel Cell Carcinoma: Evidence from a Large European Cohort of 95 Patients.

Authors:  C Ricci; A Righi; F Ambrosi; D Gibertoni; F Maletta; S Uccella; F Sessa; S Asioli; M Pellilli; R Maragliano; S La Rosa; M G Papotti; S Asioli
Journal:  Endocr Pathol       Date:  2020-03       Impact factor: 3.943

Review 4.  Merkel cell polyomavirus infection and Merkel cell carcinoma.

Authors:  Wei Liu; Margo MacDonald; Jianxin You
Journal:  Curr Opin Virol       Date:  2016-08-10       Impact factor: 7.090

5.  The prognostic significance of PD-L1 expression on tumor and immune cells in Merkel cell carcinoma.

Authors:  Morgan Guénolé; Paolo Bénigni; Vincent Bourbonne; François Lucia; Delphine Legoupil; Olivier Pradier; Laurent Misery; Arnaud Uguen; Ulrike Schick
Journal:  J Cancer Res Clin Oncol       Date:  2021-06-11       Impact factor: 4.553

6.  Selective reactivation of STING signaling to target Merkel cell carcinoma.

Authors:  Wei Liu; Gloria B Kim; Nathan A Krump; Yuqi Zhou; James L Riley; Jianxin You
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-01       Impact factor: 11.205

7.  Extended T-Cell Epitope Landscape in Merkel Cell Polyomavirus Large T and Small T Oncoproteins Identified Uniquely in Patients with Cancer.

Authors:  Ulla Kring Hansen; Rikke Lyngaa; Dafina Ibrani; Candice Church; Monique Verhaegen; Andrzej Antoni Dlugosz; Jürgen Christian Becker; Per Thor Straten; Paul Nghiem; Sine Reker Hadrup
Journal:  J Invest Dermatol       Date:  2021-07-20       Impact factor: 7.590

Review 8.  Merkel cell carcinoma of the head and neck: pathogenesis, current and emerging treatment options.

Authors:  Alok T Saini; Brett A Miles
Journal:  Onco Targets Ther       Date:  2015-08-19       Impact factor: 4.147

Review 9.  The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer.

Authors:  Ugo Moens; Kashif Rasheed; Ibrahim Abdulsalam; Baldur Sveinbjørnsson
Journal:  Viruses       Date:  2015-04-10       Impact factor: 5.048

Review 10.  Trial Watch: Immunostimulatory cytokines.

Authors:  Erika Vacchelli; Alexander Eggermont; Wolf Hervé Fridman; Jérôme Galon; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2013-05-07       Impact factor: 8.110
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