Literature DB >> 23242336

[Translational research in geriatrics? A plea based on current biomedical key publications].

L C Bollheimer1, D Volkert, T Bertsch, J Bauer, J Klucken, C C Sieber, R Büttner.   

Abstract

Contemporary geriatric research focuses mainly on observational clinical studies and epidemiological surveys and the translation of basic scientific results from biogerontology into a clinical context is often neglected. Following a definition of translational research the article gives an overview of recent key publications in experimental biogerontology with a special emphasis on their relevance for clinical geriatrics. The topics dealt with include age-induced loss of skeletal muscle (sarcopenia), the aging immune system (immunosenescence) and neurodegenerative disorders (Alzheimer's and Parkinson's disease).

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Year:  2013        PMID: 23242336     DOI: 10.1007/s00391-012-0414-3

Source DB:  PubMed          Journal:  Z Gerontol Geriatr        ISSN: 0948-6704            Impact factor:   1.281


  32 in total

Review 1.  Needle-free influenza vaccination.

Authors:  Jean-Pierre Amorij; Wouter Lj Hinrichs; Henderik W Frijlink; Jan C Wilschut; Anke Huckriede
Journal:  Lancet Infect Dis       Date:  2010-10       Impact factor: 25.071

2.  Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study.

Authors:  Toru Baba; Akio Kikuchi; Kazumi Hirayama; Yoshiyuki Nishio; Yoshiyuki Hosokai; Shigenori Kanno; Takafumi Hasegawa; Naoto Sugeno; Masatoshi Konno; Kyoko Suzuki; Shoki Takahashi; Hiroshi Fukuda; Masashi Aoki; Yasuto Itoyama; Etsuro Mori; Atsushi Takeda
Journal:  Brain       Date:  2012-01       Impact factor: 13.501

3.  Practice-based research--"Blue Highways" on the NIH roadmap.

Authors:  John M Westfall; James Mold; Lyle Fagnan
Journal:  JAMA       Date:  2007-01-24       Impact factor: 56.272

Review 4.  Resistance exercise for the aging adult: clinical implications and prescription guidelines.

Authors:  Mark D Peterson; Paul M Gordon
Journal:  Am J Med       Date:  2011-03       Impact factor: 4.965

5.  Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.

Authors:  Jincun Zhao; Jingxian Zhao; Kevin Legge; Stanley Perlman
Journal:  J Clin Invest       Date:  2011-11-21       Impact factor: 14.808

6.  Life style risks of Parkinson's disease: association between decreased water intake and constipation.

Authors:  Akira Ueki; Mieko Otsuka
Journal:  J Neurol       Date:  2004-10       Impact factor: 4.849

Review 7.  The intensity and effects of strength training in the elderly.

Authors:  Frank Mayer; Friederike Scharhag-Rosenberger; Anja Carlsohn; Michael Cassel; Steffen Müller; Jürgen Scharhag
Journal:  Dtsch Arztebl Int       Date:  2011-05-27       Impact factor: 5.594

8.  Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training.

Authors:  Frederic Derbré; Mari Carmen Gomez-Cabrera; Ana Lucia Nascimento; Fabian Sanchis-Gomar; Vladimir Essau Martinez-Bello; Jesus A F Tresguerres; Teresa Fuentes; Arlette Gratas-Delamarche; Maria Monsalve; Jose Viña
Journal:  Age (Dordr)       Date:  2011-05-18

9.  Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People.

Authors:  Alfonso J Cruz-Jentoft; Jean Pierre Baeyens; Jürgen M Bauer; Yves Boirie; Tommy Cederholm; Francesco Landi; Finbarr C Martin; Jean-Pierre Michel; Yves Rolland; Stéphane M Schneider; Eva Topinková; Maurits Vandewoude; Mauro Zamboni
Journal:  Age Ageing       Date:  2010-04-13       Impact factor: 10.668

10.  Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.

Authors:  Christopher B Forsyth; Kathleen M Shannon; Jeffrey H Kordower; Robin M Voigt; Maliha Shaikh; Jean A Jaglin; Jacob D Estes; Hemraj B Dodiya; Ali Keshavarzian
Journal:  PLoS One       Date:  2011-12-01       Impact factor: 3.240

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