Literature DB >> 23241859

[Nanomedicine. Innovative applications in medicine].

C Alexiou1.   

Abstract

Nanomedicine is a new and upcoming area in medicine. In particular, superparamagnetic iron oxide nanoparticles (SPION) deserve attention as they can be used for diagnostics and therapy ("theranostics"). For diagnosis in vivo SPION are already used as contrast agents in magnetic resonance imaging; in vitro they are used for cell separation. For therapy, magnetic drug targeting is a particularly promising approach. It enables a goal-oriented local application of active substances. Very promising animal experiments have already been performed. Moreover, SPION can be heated by alternating magnetic fields, so combination with hyperthermia is also possible. However, many effects of nanotechnology on the human organism are not known. Hence, further investigations are indispensable to elucidate possible toxic effects. Implementation of this promising therapy into the clinical setting will be possible due to interdisciplinary cooperation and respective financial support.

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Mesh:

Year:  2013        PMID: 23241859     DOI: 10.1007/s00106-012-2562-6

Source DB:  PubMed          Journal:  HNO        ISSN: 0017-6192            Impact factor:   1.284


  25 in total

Review 1.  [Nanomedicine in otorhinolaryngology--future prospects].

Authors:  S Dürr; R Tietze; S Lyer; C Alexiou
Journal:  Laryngorhinootologie       Date:  2012-01-09       Impact factor: 1.057

Review 2.  [Nanomedicine : Magnetic nanoparticles for drug delivery and hyperthermia - new chances for cancer therapy].

Authors:  C Alexiou; R Tietze; E Schreiber; S Lyer
Journal:  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz       Date:  2010-08       Impact factor: 1.513

Review 3.  Medical applications of magnetic nanoparticles.

Authors:  C Alexiou; R Jurgons; C Seliger; H Iro
Journal:  J Nanosci Nanotechnol       Date:  2006 Sep-Oct

4.  Visualization of superparamagnetic nanoparticles in vascular tissue using XμCT and histology.

Authors:  Rainer Tietze; Helene Rahn; Stefan Lyer; Eveline Schreiber; Jenny Mann; Stefan Odenbach; Christoph Alexiou
Journal:  Histochem Cell Biol       Date:  2011-01-29       Impact factor: 4.304

5.  Detection and enrichment of disseminated renal carcinoma cells from peripheral blood by immunomagnetic cell separation.

Authors:  U Bilkenroth; H Taubert; D Riemann; U Rebmann; H Heynemann; A Meye
Journal:  Int J Cancer       Date:  2001-05-15       Impact factor: 7.396

6.  Novel therapeutic nano-particles (lipocores): trapping poorly water soluble compounds.

Authors:  W R Perkins; I Ahmad; X Li; D J Hirsh; G R Masters; C J Fecko; J Lee; S Ali; J Nguyen; J Schupsky; C Herbert; A S Janoff; E Mayhew
Journal:  Int J Pharm       Date:  2000-04-25       Impact factor: 5.875

7.  Magnetic drug targeting--biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment.

Authors:  Christoph Alexiou; Roland Jurgons; Roswitha J Schmid; Christian Bergemann; Julia Henke; Wolf Erhardt; Ernst Huenges; Fritz Parak
Journal:  J Drug Target       Date:  2003-04       Impact factor: 5.121

Review 8.  Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma.

Authors:  Ken Donaldson; Fiona A Murphy; Rodger Duffin; Craig A Poland
Journal:  Part Fibre Toxicol       Date:  2010-03-22       Impact factor: 9.400

9.  Mitoxantrone loaded superparamagnetic nanoparticles for drug targeting: a versatile and sensitive method for quantification of drug enrichment in rabbit tissues using HPLC-UV.

Authors:  Rainer Tietze; Eveline Schreiber; Stefan Lyer; Christoph Alexiou
Journal:  J Biomed Biotechnol       Date:  2010-05-13

Review 10.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
Journal:  Nat Nanotechnol       Date:  2007-12       Impact factor: 39.213

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  4 in total

1.  [Risk assessment of nanoparticles in consumer products].

Authors:  S Hackenberg
Journal:  HNO       Date:  2014-06       Impact factor: 1.284

Review 2.  Cancer research by means of tissue engineering--is there a rationale?

Authors:  Raymund E Horch; Anja M Boos; Yuan Quan; Oliver Bleiziffer; Rainer Detsch; Aldo R Boccaccini; Christoph Alexiou; Jiaming Sun; Justus P Beier; Andreas Arkudas
Journal:  J Cell Mol Med       Date:  2013-10-01       Impact factor: 5.310

3.  Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.

Authors:  Xianjin Cui; Salome Belo; Dirk Krüger; Yong Yan; Rafael T M de Rosales; Maite Jauregui-Osoro; Haitao Ye; Shi Su; Domokos Mathe; Noémi Kovács; Ildikó Horváth; Mariann Semjeni; Kavitha Sunassee; Krisztian Szigeti; Mark A Green; Philip J Blower
Journal:  Biomaterials       Date:  2014-04-24       Impact factor: 12.479

4.  Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment.

Authors:  Anjali A Roeth; Ioana Slabu; Martin Baumann; Patrick H Alizai; Maximilian Schmeding; Gernot Guentherodt; Thomas Schmitz-Rode; Ulf P Neumann
Journal:  Int J Nanomedicine       Date:  2017-08-18
  4 in total

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