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Literature DB >> 23239928

Comparative analysis of genome sequences of the Th2 cytokine region of rabbit (Oryctolagus cuniculus) with those of nine different species.

E Michael Gertz¹, Richa Agarwala, Rose G Mage, Alejandro A Schäffer.

Abstract

The regions encoding the coordinately regulated Th2 cytokines IL5, IL4 and IL13 are located on chromosomes 5 of man and 11 of mouse. They have been intensively studied because these interleukins have protective roles in helminth infections, but may lead to detrimental effects such as allergy, asthma, and fibrosis in lung and liver. We added to previous studies by comparing sequences of syntenic regions on chromosome 3 of the rabbit (Oryctolagus cuniculus) genome OryCun 2.0 assembly from a tuberculosis-susceptible strain, with the corresponding region of ENCODE ENm002 from a normal rabbit as well as with 9 other mammalian species. We searched for rabbit transcription factor binding sites in putative promoter and other non-coding regions of IL5, RAD50, IL13 and IL4. Although we identified several differences between the two donor rabbits in coding and non-coding regions of potential functional significance, confirmation awaits additional sequencing of other rabbits.

Entities: Chemical Disease Gene Mutation Species

Year: 2011 PMID： 23239928 PMCID： PMC3519392 DOI： 10.4137/III.S7236

Source DB: PubMed Journal: Immunol Immunogenet Insights ISSN： 1178-6345

42 in total

1. Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee and cynomolgus macaque: phylogenetic analysis of delta2 splice variant appearance, and implications for the study of IL-4-driven immune processes.

Authors: Isabelle Gautherot; Nicolas Burdin; Delphine Seguin; Luc Aujame; Régis Sodoyer
Journal: Immunogenetics Date: 2002-11-12 Impact factor: 2.846

2. Alternatively spliced variants of interleukin-4 promote inflammation differentially.

Authors: Irina G Luzina; Virginia Lockatell; Nevins W Todd; Kendrick Highsmith; Achsah D Keegan; Jeffrey D Hasday; Sergei P Atamas
Journal: J Leukoc Biol Date: 2011-02-01 Impact factor: 4.962

3. The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not.

Authors: Keertan Dheda; Jung-Su Chang; Jim F Huggett; Louise U Kim; Margaret A Johnson; Alimuddin Zumla; Graham A W Rook
Journal: Tuberculosis (Edinb) Date: 2006-12-29 Impact factor: 3.131

4. Interchromosomal associations between alternatively expressed loci.

Authors: Charalampos G Spilianakis; Maria D Lalioti; Terrence Town; Gap Ryol Lee; Richard A Flavell
Journal: Nature Date: 2005-05-08 Impact factor: 49.962

5. Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis.

Authors: G T Seah; G M Scott; G A Rook
Journal: J Infect Dis Date: 2000-01 Impact factor: 5.226

6. Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34.

Authors: Stuart Avery; Lisa Rothwell; Winfried D J Degen; Virgil E J C Schijns; John Young; Jim Kaufman; Pete Kaiser
Journal: J Interferon Cytokine Res Date: 2004-10 Impact factor: 2.607

7. Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus.

Authors: Masakatsu Yamashita; Maki Ukai-Tadenuma; Motoko Kimura; Miyuki Omori; Masamichi Inami; Masaru Taniguchi; Toshinori Nakayama
Journal: J Biol Chem Date: 2002-08-29 Impact factor: 5.157

8. Susceptibility to tuberculosis: composition of tuberculous granulomas in Thorbecke and outbred New Zealand White rabbits.

Authors: Susana Mendez; Christine L Hatem; Anup K Kesavan; Javier Lopez-Molina; M Louise M Pitt; Arthur M Dannenberg; Yukari C Manabe
Journal: Vet Immunol Immunopathol Date: 2007-11-17 Impact factor: 2.046

Comparative analysis of genome sequences of the Th2 cytokine region of rabbit (Oryctolagus cuniculus) with those of nine different species.

1. Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee and cynomolgus macaque: phylogenetic analysis of delta2 splice variant appearance, and implications for the study of IL-4-driven immune processes.

2. Alternatively spliced variants of interleukin-4 promote inflammation differentially.

3. The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not.

4. Interchromosomal associations between alternatively expressed loci.

5. Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis.

6. Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34.

7. Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus.

8. Susceptibility to tuberculosis: composition of tuberculous granulomas in Thorbecke and outbred New Zealand White rabbits.

9. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.

10. Regulation of the Th2 cytokine locus by a locus control region.

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