Literature DB >> 23239345

Thioredoxin-1 was required for CREB activity by methamphetamine in rat pheochromocytoma cells.

Tao Lv1, Sheng-Dong Wang, Jie Bai.   

Abstract

Methamphetamine (METH) is one of the most commonly abused agents by illicit-drug users. Thioredoxin-1 (Trx-1) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control. In this study, we found that Trx-1 was induced by METH in rat pheochromocytoma PC12 cells. Furthermore, PI3K/Akt pathway was involved in METH-induced increase of Trx-1 expression. An increase in phosphorylated cAMP response element-binding protein (CREB) was also observed after exposure of PC12 cells to METH, which was inhibited by a PI3K inhibitor, LY294002. In addition, the siRNA targeted toTrx-1 reduced the level of phosphorylated CREB by METH, suggesting Trx-1 is necessary for increased activity of CREB by METH. The results obtained in this study showed that Trx-1 might play a role in the actions of METH.

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Year:  2012        PMID： 23239345     DOI： 10.1007/s10571-012-9897-0

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  36 in total

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Authors:  Erin B Larson; Danielle L Graham; Rose R Arzaga; Nicole Buzin; Joseph Webb; Thomas A Green; Caroline E Bass; Rachael L Neve; Ernest F Terwilliger; Eric J Nestler; David W Self
Journal:  J Neurosci       Date:  2011-11-09       Impact factor: 6.167

3.  CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli.

Authors:  Michel Barrot; Jocelien D A Olivier; Linda I Perrotti; Ralph J DiLeone; Olivier Berton; Amelia J Eisch; Soren Impey; Daniel R Storm; Rachael L Neve; Jerry C Yin; Venetia Zachariou; Eric J Nestler
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-06       Impact factor: 11.205

4.  Regulation of cocaine reward by CREB.

Authors:  W A Carlezon; J Thome; V G Olson; S B Lane-Ladd; E S Brodkin; N Hiroi; R S Duman; R L Neve; E J Nestler
Journal:  Science       Date:  1998-12-18       Impact factor: 47.728

Review 5.  Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets.

Authors:  Michael J Kuhar; Jason N Jaworski; George W Hubert; Kelly B Philpot; Geraldina Dominguez
Journal:  AAPS J       Date:  2005-09-02       Impact factor: 4.009

6.  Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens.

Authors:  A M Pliakas; R R Carlson; R L Neve; C Konradi; E J Nestler; W A Carlezon
Journal:  J Neurosci       Date:  2001-09-15       Impact factor: 6.167

7.  Methamphetamine-induced sensitization differentially alters pCREB and DeltaFosB throughout the limbic circuit of the mammalian brain.

Authors:  John McDaid; Martin P Graham; T Celeste Napier
Journal:  Mol Pharmacol       Date:  2006-09-01       Impact factor: 4.436

8.  Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells.

Authors:  Jie Bai; Hajime Nakamura; Yong-Won Kwon; Itaro Hattori; Yoshimi Yamaguchi; Yong-Chul Kim; Norihiko Kondo; Shin-ichi Oka; Shugo Ueda; Hiroshi Masutani; Junji Yodoi
Journal:  J Neurosci       Date:  2003-01-15       Impact factor: 6.167

9.  Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation.

Authors:  José A Morón; Srinivas Gullapalli; Chirisse Taylor; Achla Gupta; Ivone Gomes; Lakshmi A Devi
Journal:  Neuropsychopharmacology       Date:  2009-12-02       Impact factor: 7.853

10.  Regulation of gene expression and cocaine reward by CREB and DeltaFosB.

Authors:  Colleen A McClung; Eric J Nestler
Journal:  Nat Neurosci       Date:  2003-10-19       Impact factor: 24.884
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  4 in total

1.  Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents.

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Journal:  Addict Biol       Date:  2016-10-20       Impact factor: 4.280

2.  HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein.

Authors:  Jenny Shrestha; Maryline Santerre; Charles N S Allen; Sterling P Arjona; Carmen Merali; Ruma Mukerjee; Kumaraswamy Naidu Chitrala; Jin Park; Asen Bagashev; Viet Bui; Eliseo A Eugenin; Salim Merali; Marcus Kaul; Jeannie Chin; Bassel E Sawaya
Journal:  Front Aging Neurosci       Date:  2022-05-09       Impact factor: 5.702

3.  Phentermine induces conditioned rewarding effects via activation of the PI3K/Akt signaling pathway in the nucleus accumbens.

Authors:  Sa-Ik Hong; Min-Jung Kim; In-Jee You; Seung-Hwan Kwon; Shi-Xun Ma; Ji-Young Hwang; Jee-Yeon Seo; Yong-Hyun Ko; Bo Ram Lee; Seok-Yong Lee; Choon-Gon Jang
Journal:  Psychopharmacology (Berl)       Date:  2016-02-18       Impact factor: 4.530

4.  CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference.

Authors:  Juan-Antonio García-Carmona; Daymi M Camejo; Pilar Almela; Ana Jiménez; María-Victoria Milanés; Francisca Sevilla; María-Luisa Laorden
Journal:  PLoS One       Date:  2015-08-27       Impact factor: 3.240
  4 in total

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