OBJECTIVE: To investigate whether SSc increases the risk of ischaemic stroke in a large, nationwide cohort study. METHODS: From the Registry of Catastrophic Illness in Taiwan, we obtained data for 1280 patients with a diagnosis of SSc from 1997 to 2006. We also obtained data for 10 age-, gender-, comorbidity- and enrolment date-matched controls per SSc patient from the Longitudinal Health Insurance 2000. All study subjects were followed up from the date of enrolment until they developed ischaemic stroke, death or to the end of 2006, whichever was earlier. We used Cox's regression model with adjustment for age, gender and comorbid disorders to assess the independent factors in determining the risk of developing ischaemic stroke. RESULTS: We identified 1238 SSc patients and 12 380 controls. Among these patients, 765 (86 SSc patients and 679 controls) had developed ischaemic stroke during the median 4.7 years (0.1-10.0 years) of follow-up. Patients with SSc had a significantly higher incidence of ischaemic stroke when compared with controls (16.5/1000 vs 11.5/1000 person-year). After multivariate analysis, SSc was associated with a 43% increase in ischaemic stroke risk (95% CI 12%, 83%; P = 0.004). Additionally, the medication usually being prescribed among SSc patients did not alter the risk of further ischaemic stroke. CONCLUSION: We conclude that SSc is independently associated with higher risk of ischaemic stroke development.
OBJECTIVE: To investigate whether SSc increases the risk of ischaemic stroke in a large, nationwide cohort study. METHODS: From the Registry of Catastrophic Illness in Taiwan, we obtained data for 1280 patients with a diagnosis of SSc from 1997 to 2006. We also obtained data for 10 age-, gender-, comorbidity- and enrolment date-matched controls per SSc patient from the Longitudinal Health Insurance 2000. All study subjects were followed up from the date of enrolment until they developed ischaemic stroke, death or to the end of 2006, whichever was earlier. We used Cox's regression model with adjustment for age, gender and comorbid disorders to assess the independent factors in determining the risk of developing ischaemic stroke. RESULTS: We identified 1238 SSc patients and 12 380 controls. Among these patients, 765 (86 SSc patients and 679 controls) had developed ischaemic stroke during the median 4.7 years (0.1-10.0 years) of follow-up. Patients with SSc had a significantly higher incidence of ischaemic stroke when compared with controls (16.5/1000 vs 11.5/1000 person-year). After multivariate analysis, SSc was associated with a 43% increase in ischaemic stroke risk (95% CI 12%, 83%; P = 0.004). Additionally, the medication usually being prescribed among SSc patients did not alter the risk of further ischaemic stroke. CONCLUSION: We conclude that SSc is independently associated with higher risk of ischaemic stroke development.
Authors: David Ying; Milena A Gianfrancesco; Laura Trupin; Jinoos Yazdany; Eric L Greidinger; Gabriela Schmajuk Journal: J Rheumatol Date: 2019-03-15 Impact factor: 4.666
Authors: Alessandro Ricci; Hambra Di Vitantonio; Danilo De Paulis; Mattia Del Maestro; Soheila Raysi Dehcordi; Domenico Murrone; Gino Coletti; Giuseppe Calvisi; Renato Juan Galzio Journal: Surg Neurol Int Date: 2017-04-05
Authors: Sheraz A Butt; Jørgen L Jeppesen; Christian Torp-Pedersen; Flora Sam; Gunnar H Gislason; Søren Jacobsen; Charlotte Andersson Journal: J Am Heart Assoc Date: 2019-08-24 Impact factor: 5.501