Literature DB >> 23238077

Dioscin's antiviral effect in vitro.

Chaohong Liu1, Yun Wang, Chunchen Wu, Rongjuan Pei, Jianhua Song, Shiyun Chen, Xinwen Chen.   

Abstract

Dioscin is chemical compound obtained from an extract from a medical plant, air potato that is a yam species. Its potential antiviral properties were analyzed in this study. In this study, dioscin's antiviral effects were tested against several viruses including adenovirus, vesicular stomatitis virus (VSV) and hepatitis B virus (HBV). By time-of-addition assay, dioscin not only blocked the initial stage of adenovirus infection, but also affected the host cell's response for viral infection. In addition, 293 cells treated with dioscin displayed decreased mRNA levels for adenovirus receptor (CAR). Over expression of CAR in 293 cells pretreated with dioscin restored the infectivity of adenovirus. The inhibitory effect of dioscin against VSV infection was observed only in 293 cells pretreated with dioscin prior to infection. Finally, dioscin's inhibitory effect on secretion of HBeAg and HBsAg in HBV positive cell line HepG2 2.215 was observed by ELISA assay.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23238077     DOI： 10.1016/j.virusres.2012.12.001

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  7 in total

1.  Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.

Authors:  Zhang Mao; Xu Han; Dahong Chen; Youwei Xu; Lina Xu; Lianhong Yin; Huijun Sun; Yan Qi; Lingling Fang; Kexin Liu; Jinyong Peng
Journal:  Br J Pharmacol       Date:  2019-03-18       Impact factor: 8.739

2.  USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.

Authors:  Karoly Toth; Jacqueline F Spencer; Baoling Ying; Ann E Tollefson; Caroll B Hartline; Eric T Richard; Jiajun Fan; Jinglei Lyu; Boris A Kashemirov; Cheryl Harteg; Dawn Reyna; Elke Lipka; Mark N Prichard; Charles E McKenna; William S M Wold
Journal:  Antiviral Res       Date:  2018-03-03       Impact factor: 5.970

3.  Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.

Authors:  Jing Chen; Hui-Min Li; Xue-Nong Zhang; Chao-Mei Xiong; Jin-Lan Ruan
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2014-02-06

Review 4.  Natural Products: Review for Their Effects of Anti-HBV.

Authors:  Xuqiang Liu; Changyang Ma; Zhenhua Liu; Wenyi Kang
Journal:  Biomed Res Int       Date:  2020-12-09       Impact factor: 3.411

5.  Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay.

Authors:  Guan-Yu Chen; Yi-Cheng Pan; Tung-Ying Wu; Tsung-You Yao; Wei-Jan Wang; Wan-Jou Shen; Azaj Ahmed; Shu-Ting Chan; Chih-Hsin Tang; Wei-Chien Huang; Mien-Chie Hung; Juan-Cheng Yang; Yang-Chang Wu
Journal:  J Tradit Complement Med       Date:  2021-09-16

6.  Dioscin Reduces Vascular Damage in the Retina of db/db Mice by Inhibiting the VEGFA Signaling Pathway.

Authors:  Jun Wang; Guang Yan Yang; Hong Yan Sun; Ting Meng; Chu Chu Cheng; Hui Pan Zhao; Xiao Ling Luo; Ming Ming Yang
Journal:  Front Pharmacol       Date:  2022-01-28       Impact factor: 5.810

7.  Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus.

Authors:  Yu-Feng Shen; Lei Liu; Wei-Chao Chen; Yang Hu; Bin Zhu; Gao-Xue Wang
Journal:  Aquaculture       Date:  2017-09-05       Impact factor: 4.242
  7 in total

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