Literature DB >> 23238010

Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer.

Robert T Abraham1.   

Abstract

Adaptive resistance to PI3K-mTOR inhibitors potentially limits the clinical antitumor activities of these agents. In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 23238010     DOI： 10.1016/j.ccr.2012.11.012

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Increased expression of interleukin-8 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma.

Authors:  Huimin An; Yu Zhu; Huyang Xie; Yidong Liu; Weisi Liu; Qiang Fu; Dingwei Ye; Jiejie Xu
Journal:  Tumour Biol       Date:  2015-10-27

2.  Cancer Therapeutics Following Newton's Third Law.

Authors:  Ali S Arbab; Meenu Jain; Bhagelu R Achyut
Journal:  Biochem Physiol       Date:  2016

3.  Molecular mechanism of gossypol mediating CCL2 and IL‑8 attenuation in triple‑negative breast cancer cells.

Authors:  Samia S Messeha; Najla O Zarmouh; Patricia Mendonca; Carolyn Cotton; Karam F A Soliman
Journal:  Mol Med Rep       Date:  2020-06-15       Impact factor: 2.952

4.  A novel CXCL8 analog is effective in inhibiting the growth via cell cycle arrest and attenuating invasion of Lewis lung carcinoma.

Authors:  Su-Ya Hsu; Hui-Yuan Yu; Wei-Chen Lee; Chia-En Hsiao; Chih-Lung Wu; Hsi-Tsung Cheng; Li-Jin Lin; Fang Li; Yu-Ting Chou; Jya-Wei Cheng
Journal:  Onco Targets Ther       Date:  2019-09-16       Impact factor: 4.147

5.  Methyltransferase SETD2 inhibits tumor growth and metastasis via STAT1-IL-8 signaling-mediated epithelial-mesenchymal transition in lung adenocarcinoma.

Authors:  Xin Yang; Rui Chen; Yan Chen; You Zhou; Chen Wu; Qing Li; Jun Wu; Wen-Wei Hu; Wei-Qing Zhao; Wei Wei; Jun-Tao Shi; Mei Ji
Journal:  Cancer Sci       Date:  2022-02-22       Impact factor: 6.716

6.  Interaction Between CD34+ Fibrocytes and Airway Smooth Muscle Promotes IL-8 Production and Akt/PRAS40/mTOR Signaling in Asthma.

Authors:  Ting-Yu Lin; Po-Jui Chang; Chun-Yu Lo; Yu-Lun Lo; Chih-Teng Yu; Shu-Min Lin; Chih-His Scott Kuo; Horng-Chyuan Lin
Journal:  Front Med (Lausanne)       Date:  2022-04-25

7.  Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment.

Authors:  Polina Weitzenfeld; Nurit Meron; Tal Leibovich-Rivkin; Tsipi Meshel; Adit Ben-Baruch
Journal:  Mediators Inflamm       Date:  2013-12-04       Impact factor: 4.711

8.  Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response.

Authors:  Norbert Nass; Angela Dittmer; Vicky Hellwig; Theresia Lange; Johanna Mirjam Beyer; Benjamin Leyh; Atanas Ignatov; Christine Weiβenborn; Tove Kirkegaard; Anne E Lykkesfeldt; Thomas Kalinski; Jürgen Dittmer
Journal:  Oncotarget       Date:  2016-06-21

9.  Long-term exposure to carcinoma-associated fibroblasts makes breast cancer cells addictive to integrin β1.

Authors:  Angela Dittmer; Jürgen Dittmer
Journal:  Oncotarget       Date:  2018-04-24

10.  The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro.

Authors:  Javier Milara; Beatriz Ballester; Alfredo de Diego; Marta Calbet; Isabel Ramis; Montserrat Miralpeix; Julio Cortijo
Journal:  Sci Rep       Date:  2022-03-24       Impact factor: 4.996
  10 in total

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