Literature DB >> 2323778

Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15.

J M Boyle1, K H Grzeschik, P R Heath, J E Morten, P L Stern.   

Abstract

Human X rodent hybrids were stained by indirect immunofluorescence with 5T4, a murine monoclonal antibody that recognises a 72 kdalton glycoprotein expressed by human trophoblasts and a very restricted range of adult tissues; they were analysed by flow cytometry. Concordance analysis supported by segregation data allowed assignment of the gene controlling glycoprotein expression (M6P1) to chromosome 6. Similar analysis with translocation hybrids gave a regional assignment to 6q14-q15. M6P1 is distinct from NT5, coding for 5' nucleotidase, which maps to the same region.

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Year:  1990        PMID： 2323778     DOI： 10.1007/bf00195819

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  16 in total

1.  Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C.

Authors:  M G Low; J B Finean
Journal:  Biochim Biophys Acta       Date:  1978-04-20

2.  Purification of 5'-nucleotidase from human placenta after release from plasma membranes by phosphatidylinositol-specific phospholipase C.

Authors:  L F Thompson; J M Ruedi; M G Low
Journal:  Biochem Biophys Res Commun       Date:  1987-05-29       Impact factor: 3.575

3.  Transport and metabolism of 5'-nucleotidase in a rat hepatoma cell line.

Authors:  R van den Bosch; H J Geuze; A P du Maine; G J Strous
Journal:  Eur J Biochem       Date:  1986-10-01

4.  Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987).

Authors:  T B Shows; P J McAlpine; C Boucheix; F S Collins; P M Conneally; J Frézal; H Gershowitz; P N Goodfellow; J G Hall; P Issitt; C A Jones; B B Knowles; M Lewis; V A McKusick; M Meisler; N E Morton; P Rubenstein; M S Schanfield; R D Schmickel; M H Skolnick; M A Spence; G R Sutherland; M Traver; N Van Cong; H F Willard
Journal:  Cytogenet Cell Genet       Date:  1987

5.  Regional submapping of human chromosome 6 by the use of human-mouse somatic cell hybrids.

Authors:  K H Grzeschik; A Mayerová; K Bender; R Johannsmann
Journal:  Cytogenet Cell Genet       Date:  1978

6.  Assignment of ecto-5'-nucleotidase to human chromosome 6.

Authors:  J M Boyle; Y Hey; A Guerts van Kessel; M Fox
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

7.  Isolation and characterization of 5T4, a tumour-associated antigen.

Authors:  N Hole; P L Stern
Journal:  Int J Cancer       Date:  1990-01-15       Impact factor: 7.396

8.  Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.

Authors:  C J Barnstable; W F Bodmer; G Brown; G Galfre; C Milstein; A F Williams; A Ziegler
Journal:  Cell       Date:  1978-05       Impact factor: 41.582

9.  A 72 kD trophoblast glycoprotein defined by a monoclonal antibody.

Authors:  N Hole; P L Stern
Journal:  Br J Cancer       Date:  1988-03       Impact factor: 7.640

10.  Immunohistological distribution of 5T4 antigen in normal and malignant tissues.

Authors:  P J Southall; G M Boxer; K D Bagshawe; N Hole; M Bromley; P L Stern
Journal:  Br J Cancer       Date:  1990-01       Impact factor: 7.640
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  3 in total

1.  Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.

Authors:  T Sherratt; C Morelli; J M Boyle; C J Harrison
Journal:  Chromosome Res       Date:  1997-04       Impact factor: 5.239

2.  Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C-Lock linker.

Authors:  Baoying Shi; Min Wu; Zhaohui Li; Zhangming Xie; Xiaoyue Wei; Jiansheng Fan; Yingchun Xu; Ding Ding; Sajid Hamid Akash; Shuqing Chen; Sheldon Cao
Journal:  Cancer Med       Date:  2019-03-07       Impact factor: 4.452

3.  A Novel Strategy for Detection and Enumeration of Circulating Rare Cell Populations in Metastatic Cancer Patients Using Automated Microfluidic Filtration and Multiplex Immunoassay.

Authors:  Mark Jesus M Magbanua; Michael Pugia; Jin Sun Lee; Marc Jabon; Victoria Wang; Matthew Gubens; Karen Marfurt; Julia Pence; Harwinder Sidhu; Arejas Uzgiris; Hope S Rugo; John W Park
Journal:  PLoS One       Date:  2015-10-23       Impact factor: 3.240
  3 in total

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