OBJECTIVE: To optimize the extraction technique for alpha-mangostin from pericarp of Garcinia Mangostana. METHODS: The effects of ethanol concentration, ultrasonic extraction time, the liquid to solid ratio and their interaction on extraction rate were studied by central composite design. The predictive model and reliability were developed by SAS software and response surface analysis. The optimal ultrasonic extraction conditions were achieved. RESULTS: The optimal ultrasonic extraction conditions were as follows: ethanol concentration 67.8%, ultrasonic extraction time 85.9 min, the liquid to solid ratio 24.2 mL/g. Under the optimum conditions, the extraction yield of alpha-mangostin was 5.53%. CONCLUSION: This study provides an effective method for the industrial extraction of alpha-mangostin.
OBJECTIVE: To optimize the extraction technique for alpha-mangostin from pericarp of Garcinia Mangostana. METHODS: The effects of ethanol concentration, ultrasonic extraction time, the liquid to solid ratio and their interaction on extraction rate were studied by central composite design. The predictive model and reliability were developed by SAS software and response surface analysis. The optimal ultrasonic extraction conditions were achieved. RESULTS: The optimal ultrasonic extraction conditions were as follows: ethanol concentration 67.8%, ultrasonic extraction time 85.9 min, the liquid to solid ratio 24.2 mL/g. Under the optimum conditions, the extraction yield of alpha-mangostin was 5.53%. CONCLUSION: This study provides an effective method for the industrial extraction of alpha-mangostin.