BACKGROUND/AIMS: The purpose of this investigation was to determine if the long pentraxin 3 (PTX-3) may be a useful marker of intradialytic inflammation since it is rapidly released in the vasculature. METHODS: PTX-3, interleukin-6, tumor necrosis factor-α and C-reactive protein were measured before and during a hemodialysis session in 22 patients and compared with healthy subjects. The effect of dialysis with low-flux, high-flux membranes and hemodiafiltration on the inflammatory response was compared in 11 patients. RESULTS: C-reactive protein and interleukin-6 levels did not change, while a modest decrease in tumor necrosis factor-α was observed during hemodialysis. The plasma PTX-3 concentration was significantly increased (p < 0.001) after 60 min and peaked at 180 min during hemodialysis. There was no difference in the intradialytic increase in PTX-3 using different dialysis membranes and modalities. CONCLUSION: PTX-3 stands out as a rapid and sensitive marker of hemodialysis-induced inflammation. Membrane flux and hemodiafiltration did not alter the inflammatory response.
BACKGROUND/AIMS: The purpose of this investigation was to determine if the long pentraxin 3 (PTX-3) may be a useful marker of intradialytic inflammation since it is rapidly released in the vasculature. METHODS:PTX-3, interleukin-6, tumor necrosis factor-α and C-reactive protein were measured before and during a hemodialysis session in 22 patients and compared with healthy subjects. The effect of dialysis with low-flux, high-flux membranes and hemodiafiltration on the inflammatory response was compared in 11 patients. RESULTS:C-reactive protein and interleukin-6 levels did not change, while a modest decrease in tumor necrosis factor-α was observed during hemodialysis. The plasma PTX-3 concentration was significantly increased (p < 0.001) after 60 min and peaked at 180 min during hemodialysis. There was no difference in the intradialytic increase in PTX-3 using different dialysis membranes and modalities. CONCLUSION:PTX-3 stands out as a rapid and sensitive marker of hemodialysis-induced inflammation. Membrane flux and hemodiafiltration did not alter the inflammatory response.
Authors: Harmke A Polinder-Bos; Jan Willem J Elting; Marcel Jh Aries; David Vállez García; Antoon Tm Willemsen; Peter J van Laar; Johanna Kuipers; Wim P Krijnen; Riemer Hja Slart; Gert Luurtsema; Ralf Westerhuis; Ron T Gansevoort; Carlo Ajm Gaillard; Casper Fm Franssen Journal: J Cereb Blood Flow Metab Date: 2018-12-12 Impact factor: 6.200
Authors: B Sjöberg; A R Qureshi; O Heimbürger; P Stenvinkel; L Lind; A Larsson; P Bárány; J Ärnlöv Journal: J Intern Med Date: 2015-09-09 Impact factor: 8.989
Authors: Bernardo Faria; Mariana Gaya da Costa; Felix Poppelaars; Casper F M Franssen; Manuel Pestana; Stefan P Berger; Mohamed R Daha; Carlo A J M Gaillard; Marc A Seelen Journal: Front Immunol Date: 2019-08-21 Impact factor: 7.561