OBJECTIVE: To identify epidemiological trends in cutaneous neoplasms affecting equids in central North America and compare them with previously reported trends. DESIGN: Retrospective case series. SAMPLE: 3,351 cutaneous biopsy specimens from 3,272 equids with a neoplastic diagnosis. PROCEDURES: Diagnostic reports from 2 diagnostic laboratories (Colorado State University and Prairie Diagnostic Services Inc) were reviewed for frequency of specific lesions and epidemiological trends. Variables included in analyses (if known) were age, sex, breed, geographic location, date of diagnosis, location of neoplasm on the body, and presence or absence of ulceration. RESULTS: Sarcoid, squamous cell carcinoma (SCC), and melanoma were the 3 most common tumors diagnosed. Tumors associated with UV radiation (SCC, SCC in situ, hemangioma, hemangiosarcoma) were 2.3 (95% confidence interval [CI], 1.8 to 3.0) times as common in biopsy specimens received by Colorado State University than in specimens received by Prairie Diagnostic Services Inc. Appaloosa horses and American Paint horses, respectively, were 7.2 (95% CI, 5.6 to 9.2) and 4.4 (95% CI, 3.6 to 5.4) times as likely as other breeds to have tumors associated with UV radiation. Thoroughbreds were predisposed to cutaneous lymphoma, whereas Arabians were more likely to have melanomas. Draft and pony breeds were 3.1 (95% CI, 1.9 to 5.1) times as likely as other breeds to have benign soft tissue tumors. Morgans and pony breeds more commonly had basal cell tumors. Tumors in the perianal region were significantly more likely to be SCC or melanoma while tumors on the limbs were more likely to be giant cell tumor of soft parts. CONCLUSIONS AND CLINICAL RELEVANCE: Signalment, anatomic location of the mass, and geographic location of the horse can be used to help equine practitioners formulate differential diagnoses for cutaneous masses. Further research is necessary to identify the biological basis for the development of many equine cutaneous neoplasms.
OBJECTIVE: To identify epidemiological trends in cutaneous neoplasms affecting equids in central North America and compare them with previously reported trends. DESIGN: Retrospective case series. SAMPLE: 3,351 cutaneous biopsy specimens from 3,272 equids with a neoplastic diagnosis. PROCEDURES: Diagnostic reports from 2 diagnostic laboratories (Colorado State University and Prairie Diagnostic Services Inc) were reviewed for frequency of specific lesions and epidemiological trends. Variables included in analyses (if known) were age, sex, breed, geographic location, date of diagnosis, location of neoplasm on the body, and presence or absence of ulceration. RESULTS: Sarcoid, squamous cell carcinoma (SCC), and melanoma were the 3 most common tumors diagnosed. Tumors associated with UV radiation (SCC, SCC in situ, hemangioma, hemangiosarcoma) were 2.3 (95% confidence interval [CI], 1.8 to 3.0) times as common in biopsy specimens received by Colorado State University than in specimens received by Prairie Diagnostic Services Inc. Appaloosa horses and American Paint horses, respectively, were 7.2 (95% CI, 5.6 to 9.2) and 4.4 (95% CI, 3.6 to 5.4) times as likely as other breeds to have tumors associated with UV radiation. Thoroughbreds were predisposed to cutaneous lymphoma, whereas Arabians were more likely to have melanomas. Draft and pony breeds were 3.1 (95% CI, 1.9 to 5.1) times as likely as other breeds to have benign soft tissue tumors. Morgans and pony breeds more commonly had basal cell tumors. Tumors in the perianal region were significantly more likely to be SCC or melanoma while tumors on the limbs were more likely to be giant cell tumor of soft parts. CONCLUSIONS AND CLINICAL RELEVANCE: Signalment, anatomic location of the mass, and geographic location of the horse can be used to help equine practitioners formulate differential diagnoses for cutaneous masses. Further research is necessary to identify the biological basis for the development of many equinecutaneous neoplasms.
Authors: Moriel H Singer-Berk; Kelly E Knickelbein; Zachary T Lounsberry; Margo Crausaz; Savanna Vig; Nikhil Joshi; Monica Britton; Matthew L Settles; Christopher M Reilly; Ellison Bentley; Catherine Nunnery; Ann Dwyer; Mary E Lassaline; Rebecca R Bellone Journal: Int J Genomics Date: 2019-09-15 Impact factor: 2.326
Authors: Margo Crausaz; Thomas Launois; Kathryn Smith-Fleming; Annette M McCoy; Kelly E Knickelbein; Rebecca R Bellone Journal: Genes (Basel) Date: 2020-12-05 Impact factor: 4.096
Authors: Steve Horvath; Amin Haghani; Sichong Peng; Erin N Hales; Joseph A Zoller; Ken Raj; Brenda Larison; Todd R Robeck; Jessica L Petersen; Rebecca R Bellone; Carrie J Finno Journal: Nat Commun Date: 2022-01-10 Impact factor: 14.919
Authors: Giorgia Tura; Barbara Brunetti; Elena Brigandì; Riccardo Rinnovati; Giuseppe Sarli; Giancarlo Avallone; Luisa Vera Muscatello; Roberto Marcello La Ragione; Andy E Durham; Barbara Bacci Journal: Vet Sci Date: 2022-09-01