Literature DB >> 23233823

The efficacy of recombinant human activated protein C (rhAPC) vs antithrombin III (at III) vs heparin, in the healing process of partial-thickness burns: a comparative study.

O Kritikos1, M Tsagarakis, D Tsoutsos, C Kittas, V Gorgoulis, A Papalois, A Giannopoulos, G Kakiopoulos, O Papadopoulos.   

Abstract

This is an experimental study regarding the positive effect of recombinant human activated protein C (rhAPC) in the healing process of partial-thickness burns, in comparison to antithrombin III and heparin. On a porcine model we induced superficial partial-thickness and deep partial-thickness burns and performed intravenous administration of the elements of study during the first 48 h. The progress of the condition of the injured tissues was evaluated by histopathological examination at specific time intervals. The results showed an improved healing response of the specimens treated with rhAPC compared to those treated with antithrombin III, heparin, and placebo.

Entities:  

Keywords:  burns; healing; recombinant human activated protein C (rhAPC)

Year:  2012        PMID： 23233823      PMCID： PMC3506209     

Source DB:  PubMed          Journal:  Ann Burns Fire Disasters        ISSN： 1592-9558


  36 in total

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Journal:  Thromb Res       Date:  1979       Impact factor: 3.944

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Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

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Journal:  Nihon Geka Gakkai Zasshi       Date:  1991-08

10.  Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins.

Authors:  O Lider; E Baharav; Y A Mekori; T Miller; Y Naparstek; I Vlodavsky; I R Cohen
Journal:  J Clin Invest       Date:  1989-03       Impact factor: 14.808
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