PURPOSE: This study evaluated the influence of continuous infusion of diluted hydrochloric acid during radiofrequency ablation (RFA) on the size of ablated lesions. MATERIALS AND METHODS: Experiments were performed in 20 excised porcine livers using three different treatment modalities: (1) normal saline-enhanced RFA (NS-RFA), which was normal saline pumped into ablated tissue during RFA; (2) diluted hydrochloric acid ablation (DHAA), which was 3 mol/L diluted hydrochloric acid (HCl) injected into hepatic tissue without RFA; and (3) HCl-enhanced RFA (HCl-RFA), which was 3 mol/L diluted HCl continuously infused into ablated tissue during RFA. We produced 20 HCl-RFA and NS-RFA lesions, respectively, using a monopolar perfusion electrode connected to a commercially available radiofrequency generator, and 20 DHAA lesions using an 18-gauge Chiba needle. The ablated lesions were evaluated both macroscopically and histologically. Dimensions of lesions were compared among HCl-RFA, NS-RFA, and DHAA. RESULTS: The ablated lesions had an elliptical-like shape and were well-demarcated with normal liver tissue. The mean volume, longitudinal diameter, and transverse diameter of NS-RFA lesions were 11.24±0.29 cm(3), 3.4±0.07 cm, and 2.48±0.03 cm, those of HCl-RFA lesions were 58.14±3.05 cm(3), 5.51±0.05 cm, and 4.49±0.11 cm, and those of DHAA lesions were 4.41±0.16 cm(3), 2.43±0.08 cm, and 1.8±0.03 cm, respectively. The mean dimensions of HCl-RFA lesions were the largest among the three types of ablation (P < 0.001). CONCLUSION: Under the present experimental conditions, the continuous infusion of diluted HCl during RFA can generate larger ablated lesions than NS-RFA or DHAA in excised porcine livers.
PURPOSE: This study evaluated the influence of continuous infusion of diluted hydrochloric acid during radiofrequency ablation (RFA) on the size of ablated lesions. MATERIALS AND METHODS: Experiments were performed in 20 excised porcine livers using three different treatment modalities: (1) normal saline-enhanced RFA (NS-RFA), which was normal saline pumped into ablated tissue during RFA; (2) diluted hydrochloric acid ablation (DHAA), which was 3 mol/L diluted hydrochloric acid (HCl) injected into hepatic tissue without RFA; and (3) HCl-enhanced RFA (HCl-RFA), which was 3 mol/L diluted HCl continuously infused into ablated tissue during RFA. We produced 20 HCl-RFA and NS-RFA lesions, respectively, using a monopolar perfusion electrode connected to a commercially available radiofrequency generator, and 20 DHAA lesions using an 18-gauge Chiba needle. The ablated lesions were evaluated both macroscopically and histologically. Dimensions of lesions were compared among HCl-RFA, NS-RFA, and DHAA. RESULTS: The ablated lesions had an elliptical-like shape and were well-demarcated with normal liver tissue. The mean volume, longitudinal diameter, and transverse diameter of NS-RFA lesions were 11.24±0.29 cm(3), 3.4±0.07 cm, and 2.48±0.03 cm, those of HCl-RFA lesions were 58.14±3.05 cm(3), 5.51±0.05 cm, and 4.49±0.11 cm, and those of DHAA lesions were 4.41±0.16 cm(3), 2.43±0.08 cm, and 1.8±0.03 cm, respectively. The mean dimensions of HCl-RFA lesions were the largest among the three types of ablation (P < 0.001). CONCLUSION: Under the present experimental conditions, the continuous infusion of diluted HCl during RFA can generate larger ablated lesions than NS-RFA or DHAA in excised porcine livers.