| Literature DB >> 23232932 |
Yuhei Arai1, Hironobu Iinuma, Yoko Ikeda, Masayuki Igarashi, Masaki Hatano, Naoko Kinoshita, Tamami Ukaji, Siro Simizu, Kazuo Umezawa.
Abstract
In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC50 values of 1.31 and 1.99 μg ml(-1), respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.Entities:
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Year: 2012 PMID： 23232932 DOI： 10.1038/ja.2012.112
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649