Literature DB >> 2323156

Chlorpromazine disposition in relation to age in children.

M Furlanut1, P Benetello, M Baraldo, G Zara, G Montanari, F Donzelli.   

Abstract

The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children. The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (r = -0.43). It appears that the pharmacokinetics of chlorpromazine are more rapid in children than in adults.

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Year:  1990        PMID： 2323156     DOI： 10.2165/00003088-199018040-00005

Source DB:  PubMed          Journal:  Clin Pharmacokinet        ISSN： 0312-5963            Impact factor:   6.447


  7 in total

1.  Phenytoin kinetics in children.

Authors:  R G Curless; P D Walson; D E Carter
Journal:  Neurology       Date:  1976-08       Impact factor: 9.910

2.  Plasma disappearance and cerebral effects of chlorpromazine in cirrhosis.

Authors:  J D Maxwell; M Carrella; J D Parkes; R Williams; G P Mould; S H Curry
Journal:  Clin Sci       Date:  1972-08       Impact factor: 6.124

3.  Theophylline disposition in infancy.

Authors:  E G Nassif; M M Weinberger; D Shannon; S F Guiang; L Hendeles; D Jimenez; E Ekwo
Journal:  J Pediatr       Date:  1981-01       Impact factor: 4.406

4.  Pharmacokinetics of chlorpromazine in normal volunteers.

Authors:  J C Loo; K K Midha; I J McGilveray
Journal:  Commun Psychopharmacol       Date:  1980

5.  Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children.

Authors:  M Furlanut; G Montanari; P Bonin; G L Casara
Journal:  J Pediatr       Date:  1985-03       Impact factor: 4.406

6.  Electrochemical detection of benperidol in serum for drug monitoring in humans.

Authors:  M Furlanut; A Perosa; P Benetello; G Colombo
Journal:  Ther Drug Monit       Date:  1987-09       Impact factor: 3.681

7.  Plasma chlorpromazine concentrations in children with behavioral disorders and mental illness.

Authors:  L Rivera-Calimlim; P H Griesbach; R Perlmutter
Journal:  Clin Pharmacol Ther       Date:  1979-07       Impact factor: 6.875
  7 in total
  1 in total

Review 1.  Pharmacokinetic optimisation of antiemetic therapy.

Authors:  M Campbell; D N Bateman
Journal:  Clin Pharmacokinet       Date:  1992-08       Impact factor: 6.447
  1 in total

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