OBJECTIVES: Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, (131)I and (32)P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. METHODS: We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model. RESULTS: We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model. CONCLUSIONS: It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.
OBJECTIVES: Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, (131)I and (32)P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. METHODS: We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model. RESULTS: We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model. CONCLUSIONS: It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.
Authors: P J O'Dwyer; C M Mojzisik; G H Hinkle; M Rousseau; J Olsen; S E Tuttle; R F Barth; M O Thurston; D P McCabe; W B Farrar Journal: Arch Surg Date: 1986-12
Authors: Vivian E Strong; Charles J Galanis; Christopher C Riedl; Valerie A Longo; Farhad Daghighian; John L Humm; Steven M Larson; Yuman Fong Journal: Ann Surg Innov Res Date: 2009-02-21
Authors: Israt S Alam; Idan Steinberg; Ophir Vermesh; Nynke S van den Berg; Eben L Rosenthal; Gooitzen M van Dam; Vasilis Ntziachristos; Sanjiv S Gambhir; Sophie Hernot; Stephan Rogalla Journal: Mol Imaging Biol Date: 2018-10 Impact factor: 3.488
Authors: E Solfaroli Camillocci; G Baroni; F Bellini; V Bocci; F Collamati; M Cremonesi; E De Lucia; P Ferroli; S Fiore; C M Grana; M Marafini; I Mattei; S Morganti; G Paganelli; V Patera; L Piersanti; L Recchia; A Russomando; M Schiariti; A Sarti; A Sciubba; C Voena; R Faccini Journal: Sci Rep Date: 2014-03-20 Impact factor: 4.379