| Literature DB >> 23228341 |
Jones Bernardes Graceli1, Gabriela Cavati Sena, Pedro Francisco Iguatemy Lopes, Gabriela Carvalho Zamprogno, Mércia Barcellos da Costa, Ana Flavia Locateli Godoi, Dayana Moscardi Dos Santos, Mary Rosa Rodrigues de Marchi, Marcos Antonio Dos Santos Fernandez.
Abstract
The review purposes are to (1) evaluate the experimental evidence for adverse effects on reproduction and metabolism and (2) identify the current knowledge of analytical procedures, biochemistry and environmental aspects relating to organotins. Organotins are pollutants that are used as biocides in antifouling paints. They produce endocrine-disrupting effects in mollusks, such as imposex. In rodents, organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen. The adverse effects that appear in rodents have raised concerns about organotins' potential health risk to humans in relation to organotin exposure. At present, triorganotin, such as tributyltin, have been demonstrated to produce imposex, and mammalian reproductive and metabolic toxicity. For most mammals, triorganotin exposure predominantly occurs through the ingestion, and this compound can cross the placenta. With these risks in mind, it is important to improve our knowledge of organotins' effects on environmental health.Entities:
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Year: 2012 PMID： 23228341 DOI： 10.1016/j.reprotox.2012.11.008
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143