| Literature DB >> 23228030 |
Tian Tian1, Wen-He Zhong, Shuai Meng, Xiang-Bao Meng, Zhong-Jun Li.
Abstract
A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)(2)) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.Entities:
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Year: 2012 PMID： 23228030 DOI： 10.1021/jo302099d
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354