Literature DB >> 23227450

Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases.

Ganesan Ramesh1.   

Abstract

Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit. Despite improved understanding, there are no effective therapies available to treat AKI. AKI is often diagnosed late and, therefore, identification of a biomarker that will facilitate early diagnosis of AKI and provide a prognosis is desirable. The recent identification of a novel biomarker, netrin-1, that is capable of diagnosing early during the course of kidney injury has created much interest in this molecule. In this paper, we review recent progress made in understanding netrin-1 as a biomarker and therapeutic molecule for acute and chronic kidney diseases. We also discuss both the usefulness of netrin-1 as a biomarker of other diseases and as a possible therapeutic agent and relevant patents for inflammatory diseases.

Entities:  

Year:  2012        PMID： 23227450      PMCID： PMC3517172          DOI： 10.2174/2210309011202030202

Source DB:  PubMed          Journal:  Recent Pat Biomark        ISSN： 2210-3090


  62 in total

Review 1.  The Netrin family of guidance factors: emphasis on Netrin-1 signalling.

Authors:  María J Barallobre; Marta Pascual; José A Del Río; Eduardo Soriano
Journal:  Brain Res Brain Res Rev       Date:  2005-01-15

2.  DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

Authors:  D Gozuacik; S Bialik; T Raveh; G Mitou; G Shohat; H Sabanay; N Mizushima; T Yoshimori; A Kimchi
Journal:  Cell Death Differ       Date:  2008-09-19       Impact factor: 15.828

3.  DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.

Authors:  Alice Ly; Anatoly Nikolaev; Geetha Suresh; Yufang Zheng; Marc Tessier-Lavigne; Elke Stein
Journal:  Cell       Date:  2008-06-27       Impact factor: 41.582

Review 4.  Inflammation in acute kidney injury.

Authors:  Gilbert R Kinsey; Li Li; Mark D Okusa
Journal:  Nephron Exp Nephrol       Date:  2008-09-18

5.  Netrin-1 inhibits leukocyte migration in vitro and in vivo.

Authors:  Ngoc P Ly; Katsumi Komatsuzaki; Iain P Fraser; Anita A Tseng; Parthak Prodhan; Kathryn J Moore; T Bernard Kinane
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-03       Impact factor: 11.205

Review 6.  Need for better diabetes treatment for improved renal outcome.

Authors:  Peter Rossing; Dick de Zeeuw
Journal:  Kidney Int Suppl       Date:  2011-03       Impact factor: 10.545

7.  Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase.

Authors:  Vishal S Vaidya; Monika A Niewczas; Linda H Ficociello; Amanda C Johnson; Fitz B Collings; James H Warram; Andrzej S Krolewski; Joseph V Bonventre
Journal:  Kidney Int       Date:  2010-10-27       Impact factor: 10.612

8.  Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.

Authors:  J Tong; M Killeen; R Steven; K L Binns; J Culotti; T Pawson
Journal:  J Biol Chem       Date:  2001-08-30       Impact factor: 5.157

Review 9.  Netrin-1 and its dependence receptors as original targets for cancer therapy.

Authors:  Patrick Mehlen; Céline Guenebeaud
Journal:  Curr Opin Oncol       Date:  2010-01       Impact factor: 3.645

10.  Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer.

Authors:  Julien Fitamant; Céline Guenebeaud; Marie-May Coissieux; Catherine Guix; Isabelle Treilleux; Jean-Yves Scoazec; Thomas Bachelot; Agnès Bernet; Patrick Mehlen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-19       Impact factor: 11.205
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  6 in total

1.  The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease.

Authors:  Bongo Bertrand Joseph; Peng Dao Quan
Journal:  Am J Cardiovasc Dis       Date:  2013-08-16

2.  Mutations in the netrin-1 gene cause congenital mirror movements.

Authors:  Aurélie Méneret; Elizabeth A Franz; Oriane Trouillard; Thomas C Oliver; Yvrick Zagar; Stephen P Robertson; Quentin Welniarz; R J MacKinlay Gardner; Cécile Gallea; Myriam Srour; Christel Depienne; Christine L Jasoni; Caroline Dubacq; Florence Riant; Jean-Charles Lamy; Marie-Pierre Morel; Raphael Guérois; Jessica Andreani; Coralie Fouquet; Mohamed Doulazmi; Marie Vidailhet; Guy A Rouleau; Alexis Brice; Alain Chédotal; Isabelle Dusart; Emmanuel Roze; David Markie
Journal:  J Clin Invest       Date:  2017-09-25       Impact factor: 14.808

3.  Tubular injury marker netrin-1 is elevated early in experimental diabetes.

Authors:  John J White; Riyaz Mohamed; Calpurnia Jayakumar; Ganesan Ramesh
Journal:  J Nephrol       Date:  2013-08-07       Impact factor: 3.902

4.  Urinary Netrin-1: A New Biomarker for the Early Diagnosis of Renal Damage in Obese Children.

Authors:  Duygu Övünç Hacıhamdioğlu; Bülent Hacıhamdioğlu; Demet Altun; Tuba Müftüoğlu; Ferhan Karademir; Selami Süleymanoğlu
Journal:  J Clin Res Pediatr Endocrinol       Date:  2016-04-18

5.  Netrin-1 alleviates subarachnoid haemorrhage-induced brain injury via the PPARγ/NF-KB signalling pathway.

Authors:  Junhui Chen; Yong Xuan; Yan Chen; Ting Wu; Lei Chen; Haoxiang Guan; Shuo Yang; Jianqing He; Dongliang Shi; Yuhai Wang
Journal:  J Cell Mol Med       Date:  2019-01-07       Impact factor: 5.310

6.  Netrin-1 is a novel regulator of vascular endothelial function in diabetes.

Authors:  Haroldo A Toque; Aracely Fernandez-Flores; Riyaz Mohamed; Ruth B Caldwell; Ganesan Ramesh; R William Caldwell
Journal:  PLoS One       Date:  2017-10-23       Impact factor: 3.240
  6 in total

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