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Literature DB >> 23226574

Diverse roles for the paxillin family of proteins in cancer.

Nicholas O Deakin¹, Jeanine Pignatelli, Christopher E Turner.

Abstract

The paxillin family of intracellular scaffold proteins includes paxillin, Hic-5, and leupaxin, and all have been identified as key regulators of the cellular migration machinery in both 2- and 3-dimensional microenvironments. Herein, we provide insight into the roles of these proteins during tumorigenesis and metastasis, highlighting their functions in cancer initiation as well as tumor cell dissemination and survival. Furthermore, we speculate on the potential of paxillin family proteins as both future prognostic and therapeutic targets.

Entities: Disease Gene

Keywords: cell adhesion; cell survival; epithelial-mesenchymal transition (EMT); extracellular matrix (ECM); invasion

Year: 2012 PMID： 23226574 PMCID： PMC3513785 DOI： 10.1177/1947601912458582

Source DB: PubMed Journal: Genes Cancer ISSN： 1947-6019

150 in total

1. Hic-5 interacts with GIT1 with a different binding mode from paxillin.

Authors: Naoyuki Nishiya; Takeshi Shirai; Wataru Suzuki; Kiyoshi Nose
Journal: J Biochem Date: 2002-08 Impact factor: 3.387

Review 2. Integrins: bidirectional, allosteric signaling machines.

Authors: Richard O Hynes
Journal: Cell Date: 2002-09-20 Impact factor: 41.582

3. Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.

Authors: Fabienne Denhez; Sarah A Wilcox-Adelman; Peter C Baciu; Stefania Saoncella; Sohyung Lee; Becki French; Wendy Neveu; Paul F Goetinck
Journal: J Biol Chem Date: 2002-01-22 Impact factor: 5.157

4. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.

Authors: Margit Hagel; Elizabeth L George; Ann Kim; Rulla Tamimi; Sarah L Opitz; Christopher E Turner; Akira Imamoto; Sheila M Thomas
Journal: Mol Cell Biol Date: 2002-02 Impact factor: 4.272

5. Identification and characterization of hic-5/ARA55 as an hsp27 binding protein.

Authors: Y Jia; R F Ransom; M Shibanuma; C Liu; M J Welsh; W E Smoyer
Journal: J Biol Chem Date: 2001-08-23 Impact factor: 5.157

Review 6. Matrix metalloproteinase inhibitors and cancer: trials and tribulations.

Authors: Lisa M Coussens; Barbara Fingleton; Lynn M Matrisian
Journal: Science Date: 2002-03-29 Impact factor: 47.728

7. Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells.

Authors: Alison J Woods; Marnie S Roberts; Jyoti Choudhary; Simon T Barry; Yuichi Mazaki; Hisataka Sabe; Simon J Morley; David R Critchley; Jim C Norman
Journal: J Biol Chem Date: 2001-11-09 Impact factor: 5.157

8. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses.

Authors: A Bhattacharjee; W G Richards; J Staunton; C Li; S Monti; P Vasa; C Ladd; J Beheshti; R Bueno; M Gillette; M Loda; G Weber; E J Mark; E S Lander; W Wong; B E Johnson; T R Golub; D J Sugarbaker; M Meyerson
Journal: Proc Natl Acad Sci U S A Date: 2001-11-13 Impact factor: 11.205

Review 9. Strategies for MMP inhibition in cancer: innovations for the post-trial era.

Authors: Christopher Mark Overall; Carlos López-Otín
Journal: Nat Rev Cancer Date: 2002-09 Impact factor: 60.716

Review 10. Dissemination and growth of cancer cells in metastatic sites.

Authors: Ann F Chambers; Alan C Groom; Ian C MacDonald
Journal: Nat Rev Cancer Date: 2002-08 Impact factor: 60.716

38 in total

1. Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.

Authors: Padmanabhan Paranji Pattabiraman; Ponugoti Vasantha Rao
Journal: Invest Ophthalmol Vis Sci Date: 2015-08 Impact factor: 4.799

2. Expression of paxillin in laryngeal squamous cell carcinoma and its prognostic value.

Authors: Lianqing Li; Jing Wang; Lei Gao; Lili Gong
Journal: Int J Clin Exp Pathol Date: 2015-08-01

3. Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.

Authors: Yuki Ohkawa; Hiroyuki Momota; Akira Kato; Noboru Hashimoto; Yusuke Tsuda; Norihiro Kotani; Koichi Honke; Akio Suzumura; Keiko Furukawa; Yuhsuke Ohmi; Atsushi Natsume; Toshihiko Wakabayashi; Koichi Furukawa
Journal: J Biol Chem Date: 2015-05-04 Impact factor: 5.157

4. Paxillin regulated genomic networks in prostate cancer.

Authors: Xiaoting Ma; Anindita Biswas; Stephen R Hammes
Journal: Steroids Date: 2019-07-22 Impact factor: 2.668

5. Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation.

Authors: Sungsoo M Yoo; Arash Latifkar; Richard A Cerione; Marc A Antonyak
Journal: J Biol Chem Date: 2017-01-18 Impact factor: 5.157

6. Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes.

Authors: Brian H Lee; Michael R Stallcup
Journal: J Biol Chem Date: 2017-04-05 Impact factor: 5.157