Literature DB >> 23225780

N-cyano sulfoximines: COX inhibition, anticancer activity, cellular toxicity, and mutagenicity.

Seong Jun Park1, Hannah Baars, Stefanie Mersmann, Helmut Buschmann, Jens Malte Baron, Philipp M Amann, Katharina Czaja, Henner Hollert, Kerstin Bluhm, Regine Redelstein, Carsten Bolm.   

Abstract

From insects to cancer: N-Cyano sulfoximines were evaluated for COX inhibition and antiproliferative activity against a panel of cancer cell lines. The most active compound exhibited potent COX-2 inhibition, some selectivity for COX-2 over COX-1, only slight cytotoxicity towards healthy cells (HaCaT skin cells), and no mutagenic potential (as determined by an Ames assay).
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23225780     DOI： 10.1002/cmdc.201200403

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  6 in total

1.  Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.

Authors:  Christine M M Hendriks; Trevor M Penning; Tianzhu Zang; Dominik Wiemuth; Stefan Gründer; Italo A Sanhueza; Franziska Schoenebeck; Carsten Bolm
Journal:  Bioorg Med Chem Lett       Date:  2015-09-08       Impact factor: 2.823

2.  Modular Two-Step Route to Sulfondiimidamides.

Authors:  Ze-Xin Zhang; Charles Bell; Mingyan Ding; Michael C Willis
Journal:  J Am Chem Soc       Date:  2022-06-21       Impact factor: 16.383

3.  Stereospecific α-(hetero)arylation of sulfoximines and sulfonimidamides.

Authors:  Zachary P Shultz; Thomas Scattolin; Lukasz Wojtas; Justin M Lopchuk
Journal:  Nat Synth       Date:  2022-01-31

4.  Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification.

Authors:  Georg Karpel-Massler; Richard E Kast; Markus D Siegelin; Annika Dwucet; Elisabeth Schneider; Mike-Andrew Westhoff; Christian Rainer Wirtz; Xiao Yun Chen; Marc-Eric Halatsch; Carsten Bolm
Journal:  Neurochem Res       Date:  2017-08-29       Impact factor: 3.996

5.  Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer.

Authors:  Christopher C Farwell; John A McIntosh; Todd K Hyster; Z Jane Wang; Frances H Arnold
Journal:  J Am Chem Soc       Date:  2014-06-05       Impact factor: 15.419

6.  Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects.

Authors:  Christina Georgikou; Laura Buglioni; Maximilian Bremerich; Nico Roubicek; Libo Yin; Wolfgang Gross; Carsten Sticht; Carsten Bolm; Ingrid Herr
Journal:  Biomolecules       Date:  2020-05-15
  6 in total

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