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Literature DB >> 23225637

A fluorescence-based assay for p38α recruitment site binders: identification of rooperol as a novel p38α kinase inhibitor.

Jing Li¹, Tamer S Kaoud, Jake LeVieux, Brad Gilbreath, Swapna Moharana, Kevin N Dalby, Sean M Kerwin.

Abstract

A new p38α inhibitor: Using a D-recruitment site (DRS) probe for p38α which exploits covalent interaction with Cys119 and alkyne-azide "click" chemistry to identify small molecules that recognize the p38α DRS, the anti-inflammatory natural product rooperol was identified as a novel p38α inhibitor.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 23225637 PMCID： PMC3775607 DOI： 10.1002/cbic.201200529

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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