| Literature DB >> 23223627 |
Peter B Stathopulos1, Min-duk Seo, Masahiro Enomoto, Fernando J Amador, Noboru Ishiyama, Mitsuhiko Ikura.
Abstract
Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca(2+) release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca(2+) release channels.Entities:
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Year: 2012 PMID: 23223627 DOI: 10.1152/physiol.00013.2012
Source DB: PubMed Journal: Physiology (Bethesda) ISSN: 1548-9221